1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. ARL67156 trisodium salt hydrate

ARL67156 trisodium salt hydrate 

Cat. No.: HY-103265B Purity: >99.0%
Handling Instructions

ARL67156 trisodium salt hydrate is an inhibitor of ecto-ATPase. ARL67156 trisodium salt hydrate is a weak competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with Kis of 11, 18 and 12 μM, respectively. ARL67156 trisodium salt hydrate prevents in vivo the development of calcific aortic valve disease.

For research use only. We do not sell to patients.

ARL67156 trisodium salt hydrate Chemical Structure

ARL67156 trisodium salt hydrate Chemical Structure

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5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

ARL67156 trisodium salt hydrate is an inhibitor of ecto-ATPase. ARL67156 trisodium salt hydrate is a weak competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with Kis of 11, 18 and 12 μM, respectively[1]. ARL67156 trisodium salt hydrate prevents in vivo the development of calcific aortic valve disease[2].

IC50 & Target

Ki: 11 μM (NTPDase1), 18 μM (NTPDase3), 12 μM (NPP1)[1]

In Vitro

ARL67156 trisodium salt is also an effective inhibitor of UTP breakdown by superior cervical ganglion cells and to potentiate contractions elicited by this nucleotide in isolated tail artery of rat. ARL67156 is not an effective inhibitor of NTPDase2, NTPDase8, NPP3 and ecto-5′-nucleotidase (CD73), although it also reduces the activity of these enzymes[1].

In Vivo

Pre-treatment of mice with ARL67156 (2 mg/kg, i.p.), a selective inhibitor of CD39 (CD39i), completely prevents the increase of serum adenosine concentration induced by Fructose 1,6-bisphosphate (FBP; 100 mg/kg)[3].

Animal Model: C57BL/6 mice[3]
Dosage: 2 mg/kg
Administration: Pre-treated (i.p.) 1  h before administration of FBP (100 mg/kg)
Result: Completely prevented the increase of serum adenosine concentration induced by FBP.
Molecular Weight

884.14

Formula

C₁₅H₂₁Br₂N₅O₁₂P₃.₃Na.₅½H₂O

SMILES

O[[email protected]]1[[email protected]@H](O[[email protected]](COP(OP(C(Br)(Br)P(O)(O[Na])=O)(O[Na])=O)(O[Na])=O)[[email protected]]1O)N2C3=NC=NC(N(CC)CC)=C3N=C2.O.[5.5]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

ARL67156 trisodium saltPhosphataseInhibitorinhibitorinhibit

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ARL67156 trisodium salt hydrate
Cat. No.:
HY-103265B
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