2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. ARL67156 trisodium hydrate

ARL67156 trisodium hydrate  (Synonyms: FPL 67156 trisodium hydrate)

Cat. No.: HY-103265B Purity: ≥99.0%
COA Handling Instructions

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ARL67156 (FPL 67156) trisodium hydrate is a selective small is a selective samll molecular inhibitor, targeting to ecto-ATPase, CD39, and CD73. ARL67156 trisodium hydrate is also a competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with Kis of 11, 18 and 12?μM, respectively. ARL67156 trisodium hydrate can be used in the research of disease like calcific aortic valve disease, asthma.

For research use only. We do not sell to patients.

ARL67156 trisodium hydrate Chemical Structure

ARL67156 trisodium hydrate Chemical Structure

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1 mg USD 180 In-stock
5 mg USD 650 In-stock
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Based on 2 publication(s) in Google Scholar

Other Forms of ARL67156 trisodium hydrate:

ARL67156 trisodium hydrate Related Antibodies

Top Publications Citing Use of Products

2 Publications Citing Use of MCE ARL67156 trisodium hydrate

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

ARL67156 (FPL 67156) trisodium hydrate is a selective small is a selective samll molecular inhibitor, targeting to ecto-ATPase, CD39, and CD73. ARL67156 trisodium hydrate is also a competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with Kis of 11, 18 and 12?μM, respectively. ARL67156 trisodium hydrate can be used in the research of disease like calcific aortic valve disease, asthma[1][2].

IC50 & Target

Ki: 11 μM (NTPDase1), 18 μM (NTPDase3), 12 μM (NPP1)[1]; 0.97 μM (CD39), 0.45 μM (CD73)[8]
In Vitro

ARL67156 trisodium hydrate (1-100 μM) potentiates neurogenic contractions in a concentration-dependent manner[4].
ARL67156 trisodium hydrate (10 μg/mL, 24 h) increases the surface expression of CXCR3 on ATP-treated HMC-1 cells[5].
ARL67156 trisodium hydrate (30 μM, 5s) potentiates the norepinephrine release promoted by ATP in guinea pig heart synaptosomes[6].
ARL67156 trisodium hydrate (100 μM, 4h) significantly decreases HIV-1replication in macrophages[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ARL67156 trisodium hydrate Related Antibodies
In Vivo

ARL67156 trisodium hydrate (1.1 μg/kg/day, administered with osmotic pumps implanted subcutaneously, for 28 days) prevents the development of calcific aortic valve disease in Warfarin (HY-B0687)-treated rats[2].
ARL67156 trisodium hydrate (intraperitoneal injection, 2 mg/kg) prevents the increase of serum adenosine concentration induced by Fructose 1,6-bisphosphate (FBP)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Warfarin-induced mineralization rat model[2]
Dosage: 1.1 μg/kg/day
Administration: Administered with osmotic pumps implanted subcutaneously, for 28 days
Result: Prevented the development of aortic stenosis by lowering the level of apoptosis and mineralization of the aortic valve/aorta.
Normalized the level of pAkt (an important kinase involved in the survival pathway).
Animal Model: C57BL/6 mice[3]
Dosage: 2 mg/kg
Administration: Intraperitoneal injection, 1  h before administration of FBP (100 mg/kg)
Result: Completely abolished the anti-inflammatory effects of FBP (observed by the neutrophil infiltration, hyperalgesia and oedema of the joint).
Molecular Weight

834.61

Formula

C15H23Br2N5Na3O13P3
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](O[C@H](COP(OP(C(Br)(Br)P(O)(O[Na])=O)(O[Na])=O)(O[Na])=O)[C@H]1O)N2C3=NC=NC(N(CC)CC)=C3N=C2.O.[2.75]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 16.9 mg/mL (20.25 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1982 mL 5.9908 mL 11.9816 mL
5 mM 0.2396 mL 1.1982 mL 2.3963 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥99.0%

COA (261 KB) Elemental Analysis Report (119 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.1982 mL 5.9908 mL 11.9816 mL 29.9541 mL
5 mM 0.2396 mL 1.1982 mL 2.3963 mL 5.9908 mL
10 mM 0.1198 mL 0.5991 mL 1.1982 mL 2.9954 mL
15 mM 0.0799 mL 0.3994 mL 0.7988 mL 1.9969 mL
20 mM 0.0599 mL 0.2995 mL 0.5991 mL 1.4977 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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ARL67156 trisodium hydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ARL67156 trisodiumFPL 67156 trisodiumPhosphataseEcto-ATPaseNTPDaseEctonucleotidaseFBPASMCcalcific aorticATPasthmaInhibitorinhibitorinhibit

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