2761009-30-5
2761009-30-5
Chemical Structure
CXCR4 antagonist 4
- CAS. Nr.: 2761009-30-5
- Formula:C29H41F2N5
- Molecular Weight:497.67
IUPAC Name: N1-(4,4-difluorocyclohexyl)-N1-methyl-N4-(((R)-5,6,7,8-tetrahydro-1,6-naphthyridin-7-yl)methyl)-N4-((S)-5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine
InChIKey: OSKSLFQSLKWAIH-SQHAQQRYSA-N
SMILES: FC1(F)CCC(N(CCCCN([C@@H]2C3=NC=CC=C3CCC2)C[C@@H]4NCC5=C(C4)N=CC=C5)C)CC1
Biological Activity: CXCR4 antagonist 4 is a potent, orally active CXCR4 antagonist (IC50=24 nM) with diminished CYP 2D6 activity, improved PAMPA permeability, potent inhibition of human immunodeficiency virus entry (IC50=7 nM)[1].
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CXCR4 antagonist 4 | CXCR4 antagonist 4 is a potent, orally active CXCR4 antagonist (IC50=24 nM) with diminished CYP 2D6 activity, improved PAMPA permeability, potent inhibition of human immunodeficiency virus entry (IC50=7 nM). | |||||||||||||||||||||
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