Acvr2a - activin receptor IIA Gene

Also Known as Acvr2; ActrIIa; TactrII

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11480

About Acvr2a

Chromosome 2: 48,704,121-48,793,281 forward strand.GRCm39:CM000995.3

This gene has 2 transcripts (splice variants), 275 orthologues, 11 paralogues and is associated with 45 phenotypes. Broad expression in CNS E18 (RPKM 16.6), whole brain E14.5 (RPKM 12.4) and 25 other tissues.

Summary

Enables several functions, including BMP Receptor activity; PDZ domain binding activity; and activin binding activity. Acts upstream of or within several processes, including Sertoli cell proliferation; copulation; and embryonic skeletal system development. Located in cell surface. Is expressed in several structures, including central nervous system; early conceptus; gonad; gut; and sensory organ. Used to study Weissenbacher-Zweymuller syndrome. Human ortholog(s) of this gene implicated in colon Cancer. Orthologous to human ACVR2A (Activin A receptor type 2A). [provided by Alliance of Genome Resources, Apr 2022]

Acvr2a Products (1)

mRNA Protein Name
NM_007396.4 NP_031422.3 activin receptor type-2A precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables BMP receptor activity IMP
IMP: Inferred from mutant phenotype
26774823 MGI
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
16648306 MGI
enables activin binding IPI
IPI: Inferred from physical interaction
1646080 MGI
enables activin receptor activity IDA
IDA: Inferred from direct assay
8395525 MGI
enables growth factor binding IMP
IMP: Inferred from mutant phenotype
12414726 MGI
enables growth factor binding IPI
IPI: Inferred from physical interaction
11459935 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
8612709 MGI
enables inhibin binding IPI
IPI: Inferred from physical interaction
7890768 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16648306 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
17472960 MGI
involved in BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
26774823 MGI
acts upstream of or within Sertoli cell proliferation IMP
IMP: Inferred from mutant phenotype
11416011 MGI
acts upstream of or within anterior/posterior pattern specification IGI
IGI: Inferred from genetic interaction
10452853 MGI
acts upstream of or within determination of left/right symmetry IGI
IGI: Inferred from genetic interaction
16991118 MGI
acts upstream of or within embryonic skeletal system development IMP
IMP: Inferred from mutant phenotype
7885474 MGI
acts upstream of or within gastrulation with mouth forming second IGI
IGI: Inferred from genetic interaction
10452853 MGI
acts upstream of or within male gonad development IMP
IMP: Inferred from mutant phenotype
7885474 MGI
acts upstream of or within mesoderm development IGI
IGI: Inferred from genetic interaction
10452853 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IGI
IGI: Inferred from genetic interaction
16330774 MGI
acts upstream of or within penile erection IMP
IMP: Inferred from mutant phenotype
16093358 MGI
acts upstream of or within regulation of nitric oxide biosynthetic process IMP
IMP: Inferred from mutant phenotype
16093358 MGI
acts upstream of or within regulation of signal transduction IDA
IDA: Inferred from direct assay
17936261 MGI
acts upstream of or within sperm ejaculation IMP
IMP: Inferred from mutant phenotype
16093358 MGI
acts upstream of or within spermatogenesis IGI
IGI: Inferred from genetic interaction
11459797 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in cell surface IDA
IDA: Inferred from direct assay
16648306 MGI
is active in plasma membrane IDA
IDA: Inferred from direct assay
8395525 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Acvr2a Protein Structure

Activin_recp

Activin_recp: pfam01064 (58 - 113)

STKc_ACVR2a

STKc_ACVR2a: cd14141 (195 - 484)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 513 a.a.
Protein Preferred Names Protein Names

activin receptor type-2A

  • ACTR-IIA

  • activin receptor type IIA

Recombinant Acvr2a Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P75562 ACVR2A/Activin RIIA Protein, Mouse (HEK293, His-Fc) P27038 (A20-P134) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P75563 ACVR2A/Activin RIIA Protein, Mouse (HEK293, His) P27038 (A20-P134) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (1)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-P99590 Sotatercept 99.94% Unkown

Clinical Phase

Bioactive Molecules (2)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-117887 Fidrisertib Inhibitor 98.58% Phase 2
HY-157442 GLPG3312 Antagonist 98.63% Phase 1
Inhibitory Antibodies (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-P99355 Bimagrumab Inhibitor 99.31% Phase 3

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-185430 HM-279 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acvr2a NCBI NCBI:92