Rb1cc1 - RB1-inducible coiled-coil 1 Gene

Also Known as Cc1; FIP200; LaXp180; 2900055E04Rik; 5930404L04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12421

Summary

Enables protein kinase binding activity. Involved in autophagosome assembly. Acts upstream of or within several processes, including positive regulation of cell size; regulation of signal transduction; and reticulophagy. Located in autophagosome membrane; nucleus; and phagophore assembly site membrane. Part of Atg1/ULK1 kinase complex. Is expressed in several structures, including heart; musculoskeletal system; nervous system; and trunk paraxial mesenchyme. Human ortholog(s) of this gene implicated in breast Cancer. Orthologous to human RB1CC1 (RB1 inducible coiled-coil 1). [provided by Alliance of Genome Resources, Apr 2022]

Rb1cc1 Products (1)

mRNA Protein Name
NM_009826.4 NP_033956.2 RB1-inducible coiled-coil protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
19258318 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
18443221 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
17015619 MGI
involved in autophagosome assembly IDA
IDA: Inferred from direct assay
19225151 MGI
involved in autophagosome assembly IMP
IMP: Inferred from mutant phenotype
19258318 MGI
acts upstream of or within autophagy IMP
IMP: Inferred from mutant phenotype
31006538 MGI
involved in autophagy IMP
IMP: Inferred from mutant phenotype
18443221 MGI
acts upstream of or within defense response to virus IMP
IMP: Inferred from mutant phenotype
26764600 MGI
acts upstream of extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
17015619 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
17015619 MGI
acts upstream of or within innate immune response IMP
IMP: Inferred from mutant phenotype
26764600 MGI
acts upstream of or within liver development IMP
IMP: Inferred from mutant phenotype
17015619 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
17015619 MGI
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
21795849 MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
17015619 MGI
acts upstream of or within positive regulation of JNK cascade IGI
IGI: Inferred from genetic interaction
17015619 MGI
involved in positive regulation of autophagy IDA
IDA: Inferred from direct assay
19225151 MGI
acts upstream of or within positive regulation of cell size IMP
IMP: Inferred from mutant phenotype
17015619 MGI
acts upstream of or within positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
17015619 MGI
acts upstream of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
17015619 MGI
involved in regulation of protein lipidation IDA
IDA: Inferred from direct assay
19225151 MGI
acts upstream of or within reticulophagy IMP
IMP: Inferred from mutant phenotype
31006538 MGI
Cellular Component GO Annotation Evidence Verweise Source
part of Atg1/ULK1 kinase complex IDA
IDA: Inferred from direct assay
19211835 MGI
part of Atg1/ULK1 kinase complex IPI
IPI: Inferred from physical interaction
19258318 MGI
located in autophagosome membrane IDA
IDA: Inferred from direct assay
31006538 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12095676 MGI
located in phagophore assembly site IDA
IDA: Inferred from direct assay
18936157 MGI
located in phagophore assembly site membrane IDA
IDA: Inferred from direct assay
18443221 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

RB1-inducible coiled-coil protein 1

  • 200 kDa FAK family kinase-interacting protein

  • FAK family kinase-interacting protein of 200 kDa

  • coiled-coil-forming protein 1

Rb1cc1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
Rb1cc1 Q9ESK9 Atg16l1 Mus musculus Q8C0J2
Anti Bait CoIP
23262492
Intra
Rb1cc1 Q9ESK9 Atg16l1 Mus musculus Q8C0J2
Crosslink
23392225
Intra
Rb1cc1 Q9ESK9 Atg16l1 Mus musculus Q8C0J2
Y2H
23392225
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS11714 RB1CC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rb1cc1 NCBI NCBI:9821