Proc - protein C, inactivator of coagulation factors Va and VIIIa Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25268

Summary

Enables oligopeptidase activity and protein self-association. Involved in liver development; negative regulation of blood coagulation; and proteolysis. Located in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including antiphospholipid syndrome; artery disease (multiple); placental abruption; thrombophilia (multiple); and toxic shock syndrome. Orthologous to human PROC (protein C, inactivator of coagulation factors Va and VIIIa). [provided by Alliance of Genome Resources, Apr 2022]

Proc Products (1)

mRNA Protein Name
NM_012803.1 NP_036935.1 vitamin K-dependent protein C precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables identical protein binding IDA
IDA: Inferred from direct assay
1440533 RGD
enables oligopeptidase activity IDA
IDA: Inferred from direct assay
1440533 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in liver development IEP
IEP: Inferred from expression pattern
7660357 RGD
involved in negative regulation of blood coagulation IDA
IDA: Inferred from direct assay
1440533 RGD
involved in protein catabolic process IDA
IDA: Inferred from direct assay
1440533 RGD
Cellular Component GO Annotation Evidence Verweise Source
located in extracellular space IDA
IDA: Inferred from direct assay
16522789 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vitamin K-dependent protein C

  • anticoagulant protein C

  • autoprothrombin IIA

  • blood coagulation factor XIV

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-P99705 Lifastuzumab vedotin 99.03% Phase 2

Pre-clinical Phase

Bioactive Molecules (5)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-121360 Cylindrospermopsin 98.76% Unkown
HY-RS11190 PROC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-E70438 Endoproteinase Pro-C / Unkown
HY-RS17167 Proc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23617 Proc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Proc NCBI NCBI:5624