PROC - protein C, inactivator of coagulation factors Va and VIIIa Gene

Also Known as PC; APC; PROC1; THPH3; THPH4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5624

About PROC

Cytogenetic location: 2q14.3 Genomic coordinates (GRCh38): 2:127,418,427-127,429,242 (from NCBI)

This gene has 10 transcripts (splice variants), 102 orthologues, 1 paralogue and is associated with 4 phenotypes. Biased expression in liver (RPKM 55.9) and kidney (RPKM 6.8).

Summary

This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]

PROC Products (12)

mRNA	Protein	Name
NM_000312.4	NP_000303.1	vitamin K-dependent protein C isoform 10 preproprotein
NM_001375602.1	NP_001362531.1	vitamin K-dependent protein C isoform 2
NM_001375603.1	NP_001362532.1	vitamin K-dependent protein C isoform 4 precursor
NM_001375604.1	NP_001362533.1	vitamin K-dependent protein C isoform 6 precursor
NM_001375605.1	NP_001362534.1	vitamin K-dependent protein C isoform 5 preproprotein
NM_001375606.1	NP_001362535.1	vitamin K-dependent protein C isoform 3 precursor
NM_001375607.1	NP_001362536.1	vitamin K-dependent protein C isoform 1
NM_001375608.1	NP_001362537.1	vitamin K-dependent protein C isoform 9 precursor
NM_001375609.1	NP_001362538.1	vitamin K-dependent protein C isoform 8
NM_001375610.1	NP_001362539.1	vitamin K-dependent protein C isoform 7 preproprotein
NM_001375611.1	NP_001362540.1	vitamin K-dependent protein C isoform 10 preproprotein
NM_001375613.1	NP_001362542.1	vitamin K-dependent protein C isoform 10 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15248212	GOA
enables serine-type endopeptidase activity	IMP IMP: Inferred from mutant phenotype	25748729	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	12563316	GOA
involved in negative regulation of coagulation	IMP IMP: Inferred from mutant phenotype	25651845	GOA
involved in negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	25651845	GOA
involved in positive regulation of establishment of endothelial barrier	IMP IMP: Inferred from mutant phenotype	25651845	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	25748729	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	25748729	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PROC Protein Structure

Gla

FXa_inhibition

Trypsin

0
100
200
300
400
461 a.a.

Protein Preferred Names	Protein Names
vitamin K-dependent protein C	Protein C-Nagoya

PROC Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PROC	P04070	MMP15	Homo sapiens	P51511	Anti Bait CoIP	15248212
Intra	PROC	P04070	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	PROC	P04070	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PROC Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74237	Coagulation Factor XIV/PROC Protein, Human (HEK293, His)	P04070 (T19-P461)	≥ 95%, as determined by reducing SDS-PAGE.

PROC Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82716	Protein C Antibody (YA2461)	WB	Human

Related Diseases

Diseases	Alias
Thrombophilia Due To Protein C Deficiency, Autosomal Recessive	THPH4 Autosomal Recessive Thrombophilia Due To Protein C Deficiency Autosomal Recessive Protein C Deficiency Autosomal Recessive Thrombophilia Due To Pc Deficiency Autosomal Recessive Thrombophilia Due To Congenital Protein C Deficiency Hereditary Thrombophilia Due To Congenital Protein C Deficiency Severe Hereditary Thrombophilia Due To Congenital Protein C Deficiency Protein C Deficiency, Autosomal Recessive Proc Deficiency, Autosomal Recessive Thrombophilia 3 Due To Protein C Deficiency, Autosomal Recessive Autosomal Recessive Proc Deficiency Autosomal Recessive Hereditary Thrombophilia Due To Protein C Deficiency Hereditary Thrombophilia Due To Pc Deficiency Proc Deficiency Autosomal Recessive Protein C Deficiency Autosomal Recessive Thrombophilia, Hereditary, Due To Protein C Deficiency, Autosomal Recessive
Thrombophilia Due To Protein C Deficiency, Autosomal Dominant	THPH3 Thrombophilia, Hereditary, Due To Protein C Deficiency, Autosomal Dominant Protein C Deficiency, Autosomal Dominant Proc Deficiency, Autosomal Dominant Thrombophilia 3 Due To Protein C Deficiency, Autosomal Dominant Autosomal Dominant Thrombophilia Due To Protein C Deficiency Autosomal Dominant Proc Deficiency Autosomal Dominant Protein C Deficiency Proc Deficiency Autosomal Dominant Protein C Deficiency Autosomal Dominant
Protein C Deficiency	Hereditary Thrombophilia Due To Protein C Deficiency Proc Deficiency Congenital Thrombotic Disease, Due To Protein C Deficiency
Purpura Fulminans	Purpura Gangrenosa
Purpura	Purpuric Disorder
Thrombophilia	Hypercoagulability State
Thrombosis	Thrombosis Of Blood Vessel
Thrombophilia Due To Thrombin Defect	Venous Thromboembolism Venous Thrombosis Thrombophilia Due To Factor 2 Defect Thromboembolism THPH1 Thromboembolism, Susceptibility To Venous Thromboembolism, Susceptibility To Venous Thrombosis, Protection Against Prothrombin-Related Thrombophilia Hyperprothrombinemia Venous Thrombosis, Susceptibility To Thrombophilia 1 Due To Thrombin Defect F2-Related Thrombophilia Factor Ii-Related Thrombophilia Prothrombin 20210g>A Thrombophilia Prothrombin G20210a Thrombophilia Prothrombin Thrombophilia
Cerebral Palsy	Infantile Cerebral Palsy Mixed Cerebral Palsy Palsy Cerebral Palsy, Cerebral Cerebral Palsy, Mixed
Inner Ear Cancer
Internal Auditory Canal Meningioma	Meningioma Of The Internal Auditory Canal
Protein S Deficiency	Protein S Deficiency Disease Hereditary Thrombophilia Due To Protein S Deficiency
Thrombophlebitis	Phlebitis And Thrombophlebitis Of Superficial Vessels Of Lower Extremities Superficial Thrombophlebitis Of Leg Thrombophlebitis Of A Superficial Leg Vein Thrombophlebitis Of Superficial Veins Of Lower Extremity
Pulmonary Embolism	Pulmonary Artery Embolism Pulmonary Embolus Pulmonary Emboli
Neuronal Ceroid Lipofuscinosis	Hereditary Ceroid Lipofuscinosis Batten Disease Ncl Neuronal Ceroid-Lipofuscinoses Lipofuscinosis, Ceroid, Neuronal Juvenile Neuronal Ceroid Lipofuscinosis Cerebromacular Dystrophy Cerebromacular Degeneration Ceroid-Lipofuscinosis Ncl - [Neuronal Ceroid Lipofuscinosis] Amaurotic Familial Idiocy Amaurotic Idiocy Amaurotic Idiot Neuronal Lipofuscinosis Pigmentary Retinal Lipoid Neuronal Heredodegeneration
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99705	Lifastuzumab vedotin		99.03%	Phase 2

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-121360	Cylindrospermopsin		98.76%	Unkown
HY-RS11190	PROC Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-E70438	Endoproteinase Pro-C		/	Unkown
HY-RS17167	Proc Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23617	Proc Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PROC	VGNC	VGNC:56139
Mus musculus	PROC	MGD	MGI:97771
Canis familiaris	PROC	VGNC	VGNC:45006
Rattus norvegicus	PROC	RGD	RGD:3411
Others	PROC	NCBI