2. Gene
  3. PROC - protein C, inactivator of coagulation factors Va and VIIIa Gene

PROC - protein C, inactivator of coagulation factors Va and VIIIa Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PC; APC; PROC1; THPH3; THPH4

Gene ID: 5624 | Gene type: protein coding

About PROC

Cytogenetic location: 2q14.3 Genomic coordinates (GRCh38): 2:127,418,427-127,429,242 (from NCBI)

This gene has 10 transcripts (splice variants), 102 orthologues, 1 paralogue and is associated with 4 phenotypes. Biased expression in liver (RPKM 55.9) and kidney (RPKM 6.8).

Summary

This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]

PROC Products(12)

mRNA Protein Name
NM_000312.4 NP_000303.1 vitamin K-dependent protein C isoform 10 preproprotein
NM_001375602.1 NP_001362531.1 vitamin K-dependent protein C isoform 2
NM_001375603.1 NP_001362532.1 vitamin K-dependent protein C isoform 4 precursor
NM_001375604.1 NP_001362533.1 vitamin K-dependent protein C isoform 6 precursor
NM_001375605.1 NP_001362534.1 vitamin K-dependent protein C isoform 5 preproprotein
NM_001375606.1 NP_001362535.1 vitamin K-dependent protein C isoform 3 precursor
NM_001375607.1 NP_001362536.1 vitamin K-dependent protein C isoform 1
NM_001375608.1 NP_001362537.1 vitamin K-dependent protein C isoform 9 precursor
NM_001375609.1 NP_001362538.1 vitamin K-dependent protein C isoform 8
NM_001375610.1 NP_001362539.1 vitamin K-dependent protein C isoform 7 preproprotein
NM_001375611.1 NP_001362540.1 vitamin K-dependent protein C isoform 10 preproprotein
NM_001375613.1 NP_001362542.1 vitamin K-dependent protein C isoform 10 preproprotein

PROC Protein Structure

Gla

Gla: Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain (47 - 87)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (140 - 175)

Trypsin

Trypsin: Trypsin (213 - 445)

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  • 461 a.a.
Protein Preferred Names Protein Names

vitamin K-dependent protein C

Protein C-Nagoya

Recombinant PROC Proteins

Cat. No. Product Name Accession Purity
HY-P74237 Coagulation Factor XIV/PROC Protein, Human (HEK293, His) P04070 (T19-P461) ≥95%

Related Diseases

Diseases Alias
Thrombophilia Due To Protein C Deficiency, Autosomal Recessive

THPH4

Autosomal Recessive Thrombophilia Due To Protein C Deficiency

Autosomal Recessive Protein C Deficiency

Autosomal Recessive Thrombophilia Due To Pc Deficiency

Autosomal Recessive Thrombophilia Due To Congenital Protein C Deficiency

Hereditary Thrombophilia Due To Congenital Protein C Deficiency

Severe Hereditary Thrombophilia Due To Congenital Protein C Deficiency

Protein C Deficiency, Autosomal Recessive

Proc Deficiency, Autosomal Recessive

Thrombophilia 3 Due To Protein C Deficiency, Autosomal Recessive

Autosomal Recessive Proc Deficiency

Autosomal Recessive Hereditary Thrombophilia Due To Protein C Deficiency

Hereditary Thrombophilia Due To Pc Deficiency

Proc Deficiency Autosomal Recessive

Protein C Deficiency Autosomal Recessive

Thrombophilia, Hereditary, Due To Protein C Deficiency, Autosomal Recessive
Thrombophilia Due To Protein C Deficiency, Autosomal Dominant

THPH3

Thrombophilia, Hereditary, Due To Protein C Deficiency, Autosomal Dominant

Protein C Deficiency, Autosomal Dominant

Proc Deficiency, Autosomal Dominant

Thrombophilia 3 Due To Protein C Deficiency, Autosomal Dominant

Autosomal Dominant Thrombophilia Due To Protein C Deficiency

Autosomal Dominant Proc Deficiency

Autosomal Dominant Protein C Deficiency

Proc Deficiency Autosomal Dominant

Protein C Deficiency Autosomal Dominant
Protein C Deficiency

Hereditary Thrombophilia Due To Protein C Deficiency

Proc Deficiency

Congenital Thrombotic Disease, Due To Protein C Deficiency
Purpura Fulminans

Purpura Gangrenosa
Purpura

Purpuric Disorder
Thrombophilia

Hypercoagulability State
Thrombosis

Thrombosis Of Blood Vessel
Thrombophilia Due To Thrombin Defect

Venous Thromboembolism

Venous Thrombosis

Thrombophilia Due To Factor 2 Defect

Thromboembolism

THPH1

Thromboembolism, Susceptibility To

Venous Thromboembolism, Susceptibility To

Venous Thrombosis, Protection Against

Prothrombin-Related Thrombophilia

Hyperprothrombinemia

Venous Thrombosis, Susceptibility To

Thrombophilia 1 Due To Thrombin Defect

F2-Related Thrombophilia

Factor Ii-Related Thrombophilia

Prothrombin 20210g>A Thrombophilia

Prothrombin G20210a Thrombophilia

Prothrombin Thrombophilia
Cerebral Palsy

Infantile Cerebral Palsy

Mixed Cerebral Palsy

Palsy Cerebral

Palsy, Cerebral

Cerebral Palsy, Mixed
Inner Ear Cancer
Internal Auditory Canal Meningioma

Meningioma Of The Internal Auditory Canal
Protein S Deficiency

Protein S Deficiency Disease

Hereditary Thrombophilia Due To Protein S Deficiency
Thrombophlebitis

Phlebitis And Thrombophlebitis Of Superficial Vessels Of Lower Extremities

Superficial Thrombophlebitis Of Leg

Thrombophlebitis Of A Superficial Leg Vein

Thrombophlebitis Of Superficial Veins Of Lower Extremity
Pulmonary Embolism

Pulmonary Artery Embolism

Pulmonary Embolus

Pulmonary Emboli
Neuronal Ceroid Lipofuscinosis

Hereditary Ceroid Lipofuscinosis

Batten Disease

Ncl

Neuronal Ceroid-Lipofuscinoses

Lipofuscinosis, Ceroid, Neuronal

Juvenile Neuronal Ceroid Lipofuscinosis

Cerebromacular Dystrophy

Cerebromacular Degeneration

Ceroid-Lipofuscinosis

Ncl - [Neuronal Ceroid Lipofuscinosis]

Amaurotic Familial Idiocy

Amaurotic Idiocy

Amaurotic Idiot

Neuronal Lipofuscinosis

Pigmentary Retinal Lipoid Neuronal Heredodegeneration
Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99229 Upifitamab 98.77% Phase 2
Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11190 PROC Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PROC VGNC VGNC:56139
Mus musculus PROC MGD MGI:97771
Canis familiaris PROC VGNC VGNC:45006
Rattus norvegicus PROC RGD RGD:3411
Macaca fascicularis PROC NCBI
Others PROC NCBI