MMP15 - matrix metallopeptidase 15 Gene

Also Known as MMP-15; MT2MMP; MTMMP2; SMCP-2; MT2-MMP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4324

About MMP15

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:58,025,754-58,046,901 (from NCBI)

This gene has 2 transcripts (splice variants), 274 orthologues, 23 paralogues and is associated with 1 phenotype. Broad expression in thyroid (RPKM 28.2), placenta (RPKM 20.0) and 22 other tissues.

Summary

This gene encodes a member of the peptidase M10 family and membrane-type subfamily of Matrix Metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein may play a role in Cancer progression. [provided by RefSeq, Jan 2016]

MMP15 Products (1)

mRNA Protein Name
NM_002428.4 NP_002419.1 matrix metalloproteinase-15 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15248212 GOA
Biological Process GO Annotation Evidence References Source
involved in endodermal cell differentiation IEP
IEP: Inferred from expression pattern
23154389 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MMP15 Protein Structure

PG_binding_1

PG_binding_1: Putative peptidoglycan binding domain (53 - 106)

Peptidase_M10

Peptidase_M10: Matrixin (138 - 304)

Hemopexin

Hemopexin: Hemopexin (374 - 416)

Hemopexin

Hemopexin: Hemopexin (419 - 460)

Hemopexin

Hemopexin: Hemopexin (466 - 511)

Hemopexin

Hemopexin: Hemopexin (517 - 559)

DUF3377

DUF3377: Domain of unknown function (DUF3377) (609 - 669)

  • 0
  • 200
  • 400
  • 600
  • 669 a.a.
Protein Preferred Names Protein Names

matrix metalloproteinase-15

  • MT-MMP 2

MMP15 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MMP15 P51511 PROC Homo sapiens P04070
Anti Bait CoIP
15248212
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Supraglottis Cancer

  • Malignant Tumor Of Supraglottis

  • Supraglottis

  • Ca Larynx - Supraglottis

  • Malignant Neoplasm Of Extrinsic Larynx

  • Malignant Neoplasm Of Supraglottis

  • Malignant Supraglottic Tumor

  • Neoplasm Of Supraglottis
Winchester Syndrome

  • WNCHRS

  • Winchester Disease

  • Winchester-Grossman Syndrome
Arthritis

  • Inflammatory Joint Disease

  • Inflammatory Disorder Of Joint
Asymptomatic Dengue
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08531 MMP15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22644 Mmp15 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29158 Mmp15 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MMP15 VGNC VGNC:74893
Mus musculus MMP15 MGD MGI:109320
Rattus norvegicus MMP15 RGD RGD:1308937
Canis familiaris MMP15 VGNC VGNC:49926
Felis catus MMP15 VGNC VGNC:68283
Bos taurus MMP15 VGNC VGNC:31520
Others MMP15 NCBI