Protein C Antibody (YA2461)

Secreted; Golgi apparatus; Endoplasmic reticulum

Tissue_specificity:Plasma; synthesized in the liver

P04070 has 2 isomers: P04070-1: 52071 Da (predicted); P04070-2: 57556 Da (predicted).
The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium;N- and O-glycosylated. Partial (70%) N-glycosylation of Asn-371 with an atypical N-X-C site produces a higher molecular weight form referred to as alpha. The lower molecular weight form, not N-glycosylated at Asn-371, is beta. O-glycosylated with core 1 or possibly core 8 glycans;The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains;May be phosphorylated on a Ser or Thr in a region (AA 25-30) of the propeptide

Synthesized as a single chain precursor, which is cleaved into a light chain and a heavy chain held together by a disulfide bond. The enzyme is then activated by thrombin, which cleaves a tetradecapeptide from the amino end of the heavy chain; this reaction, which occurs at the surface of endothelial cells, is strongly promoted by thrombomodulin. Interacts (activated) with iripin-8, a serine protease inhibitor from Ixodes ricinus saliva (PubMed:34502392)

P04070

PROC; Vitamin K-dependent protein C; Anticoagulant protein C; Autoprothrombin IIA; Blood coagulation factor XIV

Cardiovascular