KCNJ11 - potassium inwardly rectifying channel subfamily J member 11 Gene

Also Known as BIR; HHF2; PHHI; IKATP; PNDM2; TNDM3; KIR6.2; MODY13

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3767

About KCNJ11

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:17,385,248-17,389,346 (from NCBI)

This gene has 7 transcripts (splice variants), 195 orthologues, 15 paralogues and is associated with 15 phenotypes. Broad expression in brain (RPKM 2.5), thyroid (RPKM 2.3) and 20 other tissues.

Summary

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type Potassium Channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated Insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2009]

KCNJ11 Products (4)

mRNA	Protein	Name
NM_000525.4	NP_000516.3	ATP-sensitive inward rectifier potassium channel 11 isoform 1
NM_001166290.2	NP_001159762.1	ATP-sensitive inward rectifier potassium channel 11 isoform 2
NM_001377296.1	NP_001364225.1	ATP-sensitive inward rectifier potassium channel 11 isoform 2
NM_001377297.1	NP_001364226.1	ATP-sensitive inward rectifier potassium channel 11 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables ankyrin binding	IPI IPI: Inferred from physical interaction	20610380	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19805355	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	20610380	GOA
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA IDA: Inferred from direct assay	18945825	GOA
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	18945825	GOA
enables voltage-gated potassium channel activity	IDA IDA: Inferred from direct assay	19805355	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in glucose metabolic process	IMP IMP: Inferred from mutant phenotype	8923010	GOA
involved in negative regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	8923010	GOA
involved in nervous system process	IMP IMP: Inferred from mutant phenotype	15115830	GOA
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	19805355	GOA
involved in regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	15115830	GOA
involved in regulation of membrane potential	IDA IDA: Inferred from direct assay	18073297	GOA
involved in response to ATP	IDA IDA: Inferred from direct assay	15583126	GOA
involved in response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	18073297	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of inward rectifying potassium channel	IDA IDA: Inferred from direct assay	19805355	GOA
part of inward rectifying potassium channel	IPI IPI: Inferred from physical interaction	29286281	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19805355	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNJ11 Protein Structure

IRK

0
100
200
300
390 a.a.

Protein Preferred Names	Protein Names
ATP-sensitive inward rectifier potassium channel 11	beta-cell inward rectifier subunit

KCNJ11 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	KCNJ11	Q14654	ABCC8	Homo sapiens	Q09428-1	Anti Bait CoIP	19805355
Intra	KCNJ11	Q14654	EXOSC8	Homo sapiens	Q96B26	Y2H Array	32296183
Intra	KCNJ11	Q14654	EXOSC8	Homo sapiens	Q96B26	Y2H Prey Pooling	32296183
Intra	KCNJ11	Q14654	EXOSC8	Homo sapiens	Q96B26	Validated Y2H	32296183
Intra	KCNJ11	Q14654	ANK2	Homo sapiens	Q01484	Anti Bait CoIP	19805355
Intra	KCNJ11	Q14654	ANK2	Homo sapiens	Q01484	Pull Down	19805355

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hyperinsulinemic Hypoglycemia, Familial, 2	Persistent Hyperinsulinemic Hypoglycemia Of Infancy Phhi Familial Hyperinsulinism Congenital Hyperinsulinism HHF2 Nesidioblastosis Hyperinsulinemic Hypoglycemia Due To Focal Adenomatous Hyperplasia Familial Hyperinsulinemic Hypoglycemia 2 Autosomal Recessive Hyperinsulinemic Hypoglycemia Due To Kir6.2 Deficiency Chi Congenital Isolated Hyperinsulinism Hyperinsulinemic Hypoglycemia, Persistent Hyperinsulinism, Neonatal Hyperinsulinism, Congenital Hyperinsulinism, Familial Hyperinsulinemic Hypoglycemia Familial Hyperinsulinism Congenital Hyperinsulinism Familial With Pancreatic Nesidioblastosis Hypoglycemia Hyperinsulinemic Of Infancy Nesidioblastosis Of Pancreas Hyperinsulinemic Hypoglycemia Familial 2 Hyperinsulinemia Hypoglycemia Of Infancy Infancy Hyperinsulinemia Hypoglycemia Neonatal Hyperinsulinism Persistent Hyperinsulinemia Hypoglycemia Of Infancy Persistent Hyperinsulinemic Hypoglycemia Phhi Hypoglycemia Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency Autosomal Dominant Hyperinsulinemic Hypoglycemia Due To Kir6.2 Deficiency Dominant Katp Hyperinsulinism Due To Kir6.2 Deficiency Diazoxide-Resistant Focal Hyperinsulinism Due To Kir6.2 Deficiency Hyperinsulinemic Hypoglycemia Due To Kir6.2 Deficiency, Diazoxide-Resistant Focal Form Fhi Familial Hyperinsulinemic Hypoglycemia Autosomal Recessive Hyperinsulinism Due To Kir6.2 Deficiency Hypoglycemia, Hyperinsulinemic, Familial, Type 2 Hi-C
Diabetes Mellitus, Permanent Neonatal, 2	Diabetes, Permanent Neonatal 2, With Or Without Neurologic Features PNDM2 Diabetes Mellitus, Permanent Neonatal 2 Dend1 Developmental Delay, Epilepsy, And Neonatal Diabetes 1
Maturity-Onset Diabetes Of The Young, Type 13	Maturity-Onset Diabetes Of The Young Type 13 MODY13 Mody Type 13 Mody, Type 13 Maturity-Onset Diabetes Of The Young 13 Diabetes Of The Young, Maturity-Onset, Type 13
Diabetes Mellitus, Transient Neonatal, 3	TNDM3 Diabetes Mellitus, Transient Neonatal 3 Transient Neonatal Diabetes Mellitus 3
Permanent Neonatal Diabetes Mellitus	Pndm Permanent Diabetes Mellitus Of Infancy Pdmi Neonatal Diabetes Mellitus, Permanent
Diabetes Mellitus	Diabetes
Neonatal Diabetes	Neonatal Diabetes Mellitus Diabetes Mellitus Syndrome In Newborn Infant Ndm
Diabetes Mellitus, Permanent Neonatal, 1	PNDM1 Pdmi Dend Syndrome Permanent Diabetes Mellitus Of Infancy Permanent Neonatal Diabetes Mellitus 1 Diabetes Mellitus, Permanent, Of Infancy Diabetes Mellitus, Permanent Neonatal 1 Developmental Delay-Epilepsy-Neonatal Diabetes Syndrome Dend Developmental Delay Epilepsy And Neonatal Diabetes Diabetes Mellitus Permanent Neonatal With Neurologic Features Diabetes Mellitus, Permanent Neonatal, Type 1
Pancreatic Beta Cell Agenesis With Neonatal Diabetes Mellitus	Diabetes Mellitus, Insulin-Dependent, Neonatal Neonatal Insulin-Dependent Diabetes Mellitus
Intermediate Dend Syndrome	Developmental Delay-Epilepsy-Neonatal Diabetes Syndrome, Intermediate Form
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Hyperinsulinemic Hypoglycemia	Nesidioblastosis Islet Cell Hyperplasia Persistent Hyperinsulinemia Hypoglycemia Of Infancy Hyperinsulinemic Hypoglycaemia
Hyperinsulinemic Hypoglycemia, Familial, 1	HHF1 Persistent Hyperinsulinemic Hypoglycemia Of Infancy Familial Hyperinsulinemic Hypoglycemia 1 Congenital Hyperinsulinism Phhi Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency Hypoglycemia, Hyperinsulinemic, Of Infancy Hyperinsulinemic Hypoglycemia Due To Focal Adenomatous Hyperplasia Nesidioblastosis Of Pancreas Hyperinsulinism, Familial, With Pancreatic Nesidioblastosis Hyperinsulinism, Congenital Autosomal Dominant Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency Diazoxide-Resistant Focal Hyperinsulinism Due To Sur1 Deficiency Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency, Diazoxide-Resistant Focal Form Autosomal Recessive Hyperinsulinism Due To Sur1 Deficiency Autosomal Recessive Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency Hypoglycemia, Hyperinsulinemic, Familial, Type 1
Transient Neonatal Diabetes Mellitus	Diabetes Mellitus, Transient Neonatal Tndm Chromosome 6-Associated Transient Diabetes Mellitus Dmtn Diabetes Mellitus, 6q24-Related Transient Neonatal Tndm1 Neonatal Diabetes Mellitus, Transient Tndm -[Transient Neonatal Diabetes Mellitus]
Isolated Permanent Neonatal Diabetes Mellitus	Isolated Pndm Monogenic Diabetes Of Infancy
Maturity-Onset Diabetes Of The Young	MODY Maturity Onset Diabetes Mellitus In Young Mason-Type Diabetes Mason Type Diabetes Maturity Onset Diabetes Of The Young Mody Syndrome Diabetes Of The Young, Maturity-Onset
Hypoglycemia	Hypoglycaemia Low Blood Sugar Hypoglycaemia Nos Spontaneous Hypoglycaemia Nondiabetic Hypoglycaemia Hypoglycaemic Disorder Nos Hypoglycaemic Syndrome
Hyperinsulinism	Hyperinsulinemia
Gestational Diabetes	Gestational Diabetes Mellitus GDM Diabetes Mellitus Arising In Pregnancy Maternal Gestational Diabetes Mellitus Diabetes Mellitus, Gestational Diabetes Mellitus, Pregnancy Related Diabetes, Pregnancy-Induced Diabetes Gestational Diabetes, Gestational Diabetes Of Pregnancy Gdm - [Gestational Diabetes Mellitus] Gestational Diabetes Mellitus Nos Gestational Diabetes Complicating Pregnancy, Childbirth, Or The Puerperium
Hypertrichosis
Monogenic Diabetes
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
Cantu Syndrome	Hypertrichotic Osteochondrodysplasia Hypertrichotic Osteochondrodysplasia Cantu Type Cantú Syndrome Craniofaciocardioskeletal Syndrome Hypertrichosis-Osteochondrodysplasia-Cardiomegaly Syndrome Congenital Hypertrichosis-Acromegaloid Facial Features Spectrum Congenital Hypertrichosis-Coarse Facial Features Spectrum HTOCD Osteochondrodysplasia, Hypertrichotic
Hyperglycemia
Cardiomyopathy, Dilated, 1o	Dilated Cardiomyopathy 1o CMD1O Dilated Cardiomyopathy With Ventricular Tachycardia Cardiomyopathy, Dilated, With Ventricular Tachycardia Cardiomyopathy, Dilated 1o Cardiomyopathy, Dilated, Type 1o
Chronic Duodenal Ileus
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders
Maturity-Onset Diabetes Of The Young, Type 9	Maturity-Onset Diabetes Of The Young Type 9 MODY9 Maturity-Onset Diabetes Of The Young, Type Ix Maturity-Onset Diabetes Of The Young 9 Mody-9 Mody Type 9 Diabetes Of The Young, Maturity-Onset, Type 9
Maturity-Onset Diabetes Of The Young, Type 11	Maturity-Onset Diabetes Of The Young Type 11 MODY11 Maturity-Onset Diabetes Of The Young 11 Mody-11 Mody Type 11 Diabetes Of The Young, Maturity-Onset, Type 11
Epiphyseal Dysplasia, Multiple, With Early-Onset Diabetes Mellitus	Wolcott-Rallison Syndrome Med-Iddm Syndrome Iddm-Med Syndrome Wolcott Rallison Syndrome WRS Epiphyseal Dysplasia Multiple With Early-Onset Diabetes Mellitus Early-Onset Diabetes Mellitus With Multiple Epiphyseal Dysplasia Multiple Epiphyseal Dysplasia With Early-Onset Diabetes Mellitus
Maturity-Onset Diabetes Of The Young, Type 7	Maturity-Onset Diabetes Of The Young Type 7 MODY7 Maturity-Onset Diabetes Of The Young, Type Vii Maturity-Onset Diabetes Of The Young 7 Mody-7 Mody Type 7 Diabetes Of The Young, Maturity-Onset, Type 7
Maturity-Onset Diabetes Of The Young, Type 8, With Exocrine Dysfunction	Maturity-Onset Diabetes Of The Young Type 8 MODY8 Dped Maturity-Onset Diabetes Of The Young, Type Viii Mody Type 8 Diabetes And Pancreatic Exocrine Dysfunction Diabetes-Pancreatic Exocrine Dysfunction Syndrome Diabetes And Pancreatic Exocrine Maturity-Onset Diabetes Of The Young Type 8 With Exocrine Dysfunction Maturity-Onset Diabetes Of The Young 8 With Exocrine Dysfunction Diabetes And Pancreatic Exocrine Dysfunction Syndrome Mody-8 Diabetes Of The Young, Maturity-Onset, Type 8
Wolfram Syndrome 1	WFS1 Didmoad Wfs Diabetes Mellitus And Insipidus With Optic Atrophy And Deafness Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Syndrome Wolfram Syndrome
Maturity-Onset Diabetes Of The Young, Type 14	Maturity-Onset Diabetes Of The Young Type 14 MODY14 Maturity-Onset Diabetes Of The Young 14 Diabetes Of The Young, Maturity-Onset, Type 14
Glucose Intolerance	Glucose: Intolerance Glucose: Malabsorption Malabsorption Of Glucose Impaired Glucose Tolerance
Maturity-Onset Diabetes Of The Young, Type 2	Maturity-Onset Diabetes Of The Young Type 2 MODY2 Mody Glucokinase-Related Mody Type 2 Mody, Type 2 Mody, Glucokinase-Related Mody, Type Ii Maturity-Onset Diabetes Of The Young 2 Mody-2 Diabetes Of The Young, Maturity-Onset, Type 2 Diabetes Mellitus Autosomal Dominant Type Ii
Munchausen By Proxy	Munchausen Syndrome By Proxy Munchausen By Proxy Syndrome Münchausen Syndrome By Proxy
Maturity-Onset Diabetes Of The Young, Type 10	Maturity-Onset Diabetes Of The Young Type 10 MODY10 Maturity-Onset Diabetes Of The Young 10 Mody-10 Mody Type 10 Diabetes Of The Young, Maturity-Onset, Type 10
Maturity-Onset Diabetes Of The Young, Type 1	Maturity-Onset Diabetes Of The Young Type 1 MODY1 Mild Juvenile Diabetes Mellitus Mody, Type I Diabetes Mellitus Type 2 Mody Type 1 Mody, Type 1 Maturity-Onset Diabetes Of The Young 1 Mody-1 Diabetes Of The Young, Maturity-Onset, Type 1
Maturity-Onset Diabetes Of The Young, Type 4	Maturity-Onset Diabetes Of The Young Type 4 MODY4 Mody, Type Iv Mody Type 4 Mody, Type 4 Maturity-Onset Diabetes Of The Young 4 Mody-4 Diabetes Of The Young, Maturity-Onset, Type 4 Maturity-Onset Diabetes Of The Young, Type Iv
Maturity-Onset Diabetes Of The Young, Type 6	MODY6 Maturity-Onset Diabetes Of The Young Type 6 Maturity-Onset Diabetes Of The Young 6 Mody Type 6 Mody, Type 6 Mody-6 Diabetes Of The Young, Maturity-Onset, Type 6
Maturity-Onset Diabetes Of The Young, Type 3	Maturity-Onset Diabetes Of The Young Type 3 MODY3 Mody, Type Iii Mody Type 3 Mody, Type 3 Maturity-Onset Diabetes Of The Young 3 Mody-3 Diabetes Of The Young, Maturity-Onset, Type 3
Hyperinsulinemic Hypoglycemia, Familial, 6	Hyperinsulinism-Hyperammonemia Syndrome HHF6 Familial Hyperinsulinemic Hypoglycemia 6 Hi/Ha Syndrome Ha/Hi Syndrome Hyperinsulinemic Hypoglycemia Familial 6 Hyperinsulinism Hyperammonemia Syndrome Hhs
Renal Cysts And Diabetes Syndrome	RCAD Mody5 Congenital Anomalies Of The Kidney And Urinary Tract With Diabetes Cakut With Diabetes Maturity-Onset Diabetes Of The Young Type 5 Tubulointerstitial Kidney Disease, Autosomal Dominant, 3 Adtkd3 Atypical Familial Juvenile Hyperuricemic Nephropathy Atypical Fjhn Familial Hypoplastic Glomerulocystic Kidney Maturity-Onset Diabetes Of The Young, Type 5 Hyperuricemic Nephropathy, Familial Juvenile, Atypical Fjhn, Atypical Glomerulocystic Kidney Disease, Hypoplastic Type Glomerulocystic Kidney, Familial Hypoplastic Hypoplastic Type Glomerulocystic Kidney Disease Glomerulocystic Kidney Disease Hypoplastic Type Renal-Diabetes Mody5 Syndrome
Asphyxia Neonatorum	Birth Asphyxia Postnatal Asphyxia Asphyxia - Birth Asphyxia, In Liveborn Infant Hypoxia Neonatorum Hypoxia, In Liveborn Infant Intrapartum Asphyxia Neonatal Asphyxia Newborn Asphyxia Asphyxia In Liveborn Infant Asphyxia Of Newborn Nos Perinatal Asphyxia Perinatal Hypoxia Newborn Asphyxiation
Pancreatic Agenesis	Partial Pancreatic Agenesis Congenital Pancreatic Agenesis Partial Agenesis Of The Pancreas Agenesis, Pancreatic Pancreatic Agenesis, Congenital
Prediabetes Syndrome	Prediabetes Impaired Glucose Tolerance Prediabetic State IGT Igt - [Impaired Glucose Tolerance] Impaired Glucose Tolerance With Unspecified Complication Impaired Glucose Tolerance Without Complication Abnormal Glucose Tolerance
Hyperinsulinemic Hypoglycemia, Familial, 7	HHF7 Exercise-Induced Hyperinsulinemic Hypoglycemia Exercise-Induced Hyperinsulinism Familial Hyperinsulinemic Hypoglycemia 7 Eihi Hyperinsulinism Due To Monocarboxylate Transporter 1 Deficiency Hyperinsulinism Due To Slc16a1 Deficiency Hyperinsulinemic Hypoglycemia, Exercise-Induced Exercise Induced Hyperinsulinemic Hypoglycemia Hyperinsulinemic Hypoglycemia Exercise-Induced Hyperinsulinemic Hypoglycemia Familial 7
Factitious Disorder	Munchausen Syndrome Factitious Disorders Münchausen Syndrome
Hypoglycemia, Leucine-Induced	Leucine-Sensitive Hypoglycemia Of Infancy Leucine-Induced Hypoglycemia LIH Hypoglycemia Of Infancy, Leucine-Sensitive Familial Infantile Hypoglycemia Precipitated By Leucine Hypoglycemia Leucine Induced Hypoglycemia Leucine-Induced
Developmental Coordination Disorder	Motor Skills Disorders
Wolfram Syndrome	Didmoad Syndrome Didmoad Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Wfs Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness Didmoadud Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome
Diabetes Mellitus, Ketosis-Prone	Diabetic Ketoacidosis KPD Diabetes Mellitus, Ketosis-Prone, Susceptibility To Ketosis-Prone Diabetes Mellitus Diabetes Mellitus, Insulin-Dependent Diabetic Ketoacidosis Nos Dka - [Diabetic Ketoacidosis] Nos Dka - [Diabetic Ketoacidosis] Without Coma Dka - [Diabetic Ketoacidosis] With Coma
Coronary Artery Vasospasm	Coronary Vasospasm Coronary Artery Spasm
Fetal Erythroblastosis	Erythroblastosis, Fetal Ef - Erythroblastosis Foetalis Erythroblastosis Fetalis Haemolytic Disease Due To Rhesus Isoimmunisation Rhesus Isoimmunisation Of The Newborn
Type 1 Diabetes Mellitus 12	Diabetes Mellitus, Insulin-Dependent, 12 IDDM12 Insulin-Dependent Diabetes Mellitus 12 T1D12 Type 1 Diabetes Mellitus 12, Susceptibility To Diabetes Mellitus, Insulin-Dependent, Type 12
Andersen Cardiodysrhythmic Periodic Paralysis	Andersen Syndrome Andersen-Tawil Syndrome LQT7 Long Qt Syndrome 7 Ats Periodic Paralysis, Potassium-Sensitive Cardiodysrhythmic Type Long Qt Syndrome Type 7 Andersen Tawil Syndrome Potassium-Sensitive Cardiodysrhythmic Type Lqts Type 7 Long Qt Syndrome-7
Umbilical Hernia	Hernia, Umbilical
Hypokalemic Periodic Paralysis, Type 1	Hypokalemic Periodic Paralysis Hokpp Hypopp Westphall Disease HOKPP1 Familial Hypokalemic Periodic Paralysis Familial Periodic Paralysis Westphal Disease Hypokalemic Periodic Paralysis Type 1 Hypokalemic Familial Periodic Paralysis Periodic Hypokalemic Paralysis Periodic Paralysis I Hypokpp Primary Hypokalemic Periodic Paralysis Periodic Paralysis Hypokalemic 1 Paralysis, Hypokalemic, Periodic Paralysis, Hypokalemic, Periodic, Type 1
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Long Qt Syndrome 1	Romano-Ward Syndrome LQT1 Ward-Romano Syndrome Rws Ventricular Fibrillation With Prolonged Qt Interval Wrs Long Qt Syndrome 1, Acquired, Susceptibility To Long Qt Syndrome 1, Acquired Romano-Ward Long Qt Syndrome Long Qt Syndrome Type 1 Long Qt Syndrome-1 Acquired Susceptibility To Long Qt Syndrome 1 Qt Syndrome, Long, Type 1
Brugada Syndrome	Sudden Unexpected Nocturnal Death Syndrome Sudden Unexplained Nocturnal Death Syndrome Bangungut Brugada Type Idiopathic Ventricular Fibrillation Pokkuri Death Syndrome Sunds Idiopathic Ventricular Fibrillation, Brugada Type Sudden Unexplained Death Dream Disease Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome Sudden Unexplained Death Syndrome Suds Sunds - [Sudden Unexplained Nocturnal Death Syndrome]
Beckwith-Wiedemann Syndrome	Wiedemann-Beckwith Syndrome BWS Exomphalos-Macroglossia-Gigantism Syndrome Emg Syndrome Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation Emg Abnormality Wbs Exomphalos Macroglossia Gigantism Syndrome Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation Macroglossia Exomphalos Gigantism
Long Qt Syndrome	Romano-Ward Syndrome Long Q-T Syndrome Lqt Qt Syndrome, Long Congenital Long Qt Syndrome Familial Long Qt Syndrome
Familial Atrial Fibrillation	Atrial Fibrillation, Familial Atfb Atrial Fibrillation Autosomal Dominant Autosomal Dominant Atrial Fibrillation Auricular Fibrillation Atrial Fibrillation Atrial Fibrillation, Familial, 1
Patent Ductus Arteriosus 1	Patent Ductus Arteriosus PDA1 Pda Ductus Arteriosus, Patent Patent Ductus Arteriosus, Susceptibility To Patent Ductus Botalli Patency Of The Ductus Arteriosus Patent Ductus Arteriosus Familial Ductus Arteriosus Patent Patent Ductus Arteriosus - Persisting Type
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS07138	KCNJ11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	KCNJ11	VGNC	VGNC:42259
Mus musculus	KCNJ11	MGD	MGI:107501
Rattus norvegicus	KCNJ11	RGD	RGD:69247
Bos taurus	KCNJ11	VGNC	VGNC:30455
Felis catus	KCNJ11	VGNC	VGNC:67911
Others	KCNJ11	NCBI