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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
34 Results for "
Manage
" in MedChemExpress (MCE) Product Catalog:
Products (34)
34 Results for "Manage" in MCE Product Catalog:
Art. -Nr.: HY-111011
CAS. Nr.: 958873-83-1
Synonyms: JNJ 38488502 acetate; FE 200665 acetate
Target:
Forschungsgebiete:
CR 665 (JNJ 38488502) acetate is a kappa-opioid agonist that may effectively treat visceral pain by activating receptors on afferent nerves within the gut. CR 665 acetate exhibits peripheral selectivity, differentiating its pharmacokinetic profile from that of non-selective opioids like oxycodone. CR 665 acetate has demonstrated a beneficial effect on visceral pain tolerance thresholds without the delayed analgesic response characteristic of opioids that penetrate the brain. CR 665 acetate is proposed for use in managing postoperative pain due to its pain-relieving properties.
Art. -Nr.: HY-122010
CAS. Nr.: 300842-59-5
NVP-AAD777 is a specific inhibitor of VEGFR-2, demonstrated in vivo by its effective suppression of phospho-VEGFR-2 (Tyr1175) signaling in rat lung tissues. Unlike the nonspecific VEGFR inhibitor SUG-5416, NVP-AAD777 did not induce emphysematous changes in the lungs after three weeks of treatment, even when combined with exposure to cigarette smoke. Additionally, there were no alterations observed in vascular density compared to control animals. This indicates NVP-AAD777's targeted action in inhibiting VEGFR-2 without adverse pulmonary effects, highlighting its potential therapeutic utility in managing conditions associated with aberrant VEGFR-2 signaling .
Art. -Nr.: HY-15026
CAS. Nr.: 915798-75-3
Target:
Forschungsgebiete:
ATB-429, a novel H2S-releasing derivative of mesalamine, demonstrates significant anti-nociceptive and anti-inflammatory effects in models of irritable bowel syndrome (IBS). By releasing hydrogen sulfide (H2S), ATB-429 modulates colorectal distension-induced hypersensitivity in both healthy and postcolitic rats. It attenuates abdominal withdrawal responses and suppresses spinal c-Fos mRNA expression, indicating its potential to alleviate pain associated with gastrointestinal inflammation. Moreover, ATB-429 down-regulates colonic cyclooxygenase-2 and interleukin-1β mRNA expression, effects not observed with mesalamine alone. The mechanism involves ATP-sensitive K+ (KATP) channels, as evidenced by reversal of ATB-429's effects with glibenclamide. These findings suggest ATB-429 could offer therapeutic benefits for managing painful intestinal disorders linked to inflammation .
Art. -Nr.: HY-B1850R
CAS. Nr.: 100784-20-1
Synonyms: Inpool (Standard); MON 12000 (Standard); Manage (Standard)
Target:
Forschungsgebiete:
Halosulfuron-methyl (Standard) is the analytical standard of Halosulfuron-methyl. This product is intended for research and analytical applications. Halosulfuron-methyl is a pyrazole sulfonylurea herbicide .
Art. -Nr.: HY-185451
CAS. Nr.: 2158274-50-9
Herbicidal agent 15 is a uracilpyridine herbicide. Herbicidal agent 15 controls harmful plants and acts on plants, their seeds, and their habitat to manage unwanted vegetation .
Art. -Nr.: HY-FLB0372A
CAS. Nr.: 611-75-6
Forschungsgebiete:
Bromhexine hydrochloride solution is mainly composed of Bromhexine hydrochloride (HY-B0372A). Bromhexine hydrochloride is a potent and specific TMPRSS2 protease inhibitor with an IC50 of 0.75 μM. Bromhexine hydrochloride can prevent and manage SARS-CoV-2 infection. Bromhexine hydrochloride is an autophagy agonist. Bromhexine hydrochloride is a mucolytic cough suppressant and has the potential for a range of respiratory conditions .
Art. -Nr.: HY-W040286R
CAS. Nr.: 94593-91-6
Cinosulfuron (Standard) is the analytical standard of Cinosulfuron. This product is intended for research and analytical applications. Cinosulfuron is a selective herbicide with excellent inhibitory activity against a variety of broadleaf weeds and is widely used in crop fields to protect the growth of crops. Cinosulfuron can effectively manage weed problems by inhibiting specific enzyme activity. Cinosulfuron is used in agriculture to increase crop yield and quality and ensure efficient use of farmland.
Art. -Nr.: HY-N19069
Art. -Nr.: HY-162898
CAS. Nr.: 2983120-29-0
Anti-virulence factor-IN-1 (Compound 4S) is a bacterial virulence factor inhibitor by interfering with the bacterial infection process. Anti-virulence factor-IN-1 exhibits an antibacterial activity against Xoo in vitro with an EC50 value of 0.28 µg/mL. Anti-virulence factor-IN-1 can be used to effectively manage rice bacterial leaf blight in vivo. Anti-virulence factor-IN-1 is promising for research of plant bacterial disease .
Art. -Nr.: HY-13777C
CAS. Nr.: 131654-46-1
Synonyms: CGP 42446 disodium; CGP42446A disodium; ZOL 446 disodium
Zoledronate (CGP 42446) disodium is a potent bisphosphonate that effectively inhibits osteoclastogenesis, reducing bone turnover and stabilizing the bone matrix. Zoledronate disodium has demonstrated notable effectiveness in managing Paget's disease of bone by suppressing metabolic activity and alleviating bone pain. Zoledronate disodium is being investigated in the ongoing ZiPP trial for its potential to prevent disease progression in patients with Paget's disease. Zoledronate disodium also exhibits diverse anti-tumor effects in osteosarcoma, further highlighting its multifunctional therapeutic applications.
Art. -Nr.: HY-N18750
CAS. Nr.: 89997-35-3
Art. -Nr.: HY-N19083
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
