131654-46-1
Chemical Structure
Zoledronate disodium
Synonym(s): CGP 42446 disodium; CGP42446A disodium; ZOL 446 disodium
- CAS No.: 131654-46-1
- Formula:C5H8N2Na2O7P2
- Molecular Weight:316.05
InChIKey: OPQQEYHAVUNQNA-UHFFFAOYSA-L
SMILES: O=P(O)(C(CN1C=NC=C1)(P(O[Na])(O[Na])=O)O)O
Biological Activity: Zoledronate (CGP 42446) disodium is a potent bisphosphonate that effectively inhibits osteoclastogenesis, reducing bone turnover and stabilizing the bone matrix. Zoledronate disodium has demonstrated notable effectiveness in managing Paget's disease of bone by suppressing metabolic activity and alleviating bone pain. Zoledronate disodium is being investigated in the ongoing ZiPP trial for its potential to prevent disease progression in patients with Paget's disease. Zoledronate disodium also exhibits diverse anti-tumor effects in osteosarcoma, further highlighting its multifunctional therapeutic applications.
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Zoledronate disodium | Zoledronate (CGP 42446) disodium is a potent bisphosphonate that effectively inhibits osteoclastogenesis, reducing bone turnover and stabilizing the bone matrix. Zoledronate disodium has demonstrated notable effectiveness in managing Paget's disease of bone by suppressing metabolic activity and alleviating bone pain. Zoledronate disodium is being investigated in the ongoing ZiPP trial for its potential to prevent disease progression in patients with Paget's disease. Zoledronate disodium also exhibits diverse anti-tumor effects in osteosarcoma, further highlighting its multifunctional therapeutic applications. | |||||||||||||||||||||
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