2. PROTAC
  3. PROTAC Linkers
  4. Azido-PEG5-triethoxysilane

Azido-PEG5-triethoxysilane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG5-triethoxysilane is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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Azido-PEG5-triethoxysilane Chemical Structure

Azido-PEG5-triethoxysilane Chemical Structure

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Based on 1 publication(s) in Google Scholar

Azido-PEG5-triethoxysilane Related Antibodies

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Description

Azido-PEG5-triethoxysilane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG5-triethoxysilane is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Azido-PEG5-triethoxysilane Related Antibodies
Molecular Weight

538.71

Formula

C22H46N4O9Si
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(NCCC[Si](OCC)(OCC)OCC)CCOCCOCCOCCOCCOCCN=[N+]=[N-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (464.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8563 mL 9.2814 mL 18.5629 mL
5 mM 0.3713 mL 1.8563 mL 3.7126 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8563 mL 9.2814 mL 18.5629 mL 46.4072 mL
5 mM 0.3713 mL 1.8563 mL 3.7126 mL 9.2814 mL
10 mM 0.1856 mL 0.9281 mL 1.8563 mL 4.6407 mL
15 mM 0.1238 mL 0.6188 mL 1.2375 mL 3.0938 mL
20 mM 0.0928 mL 0.4641 mL 0.9281 mL 2.3204 mL
25 mM 0.0743 mL 0.3713 mL 0.7425 mL 1.8563 mL
30 mM 0.0619 mL 0.3094 mL 0.6188 mL 1.5469 mL
40 mM 0.0464 mL 0.2320 mL 0.4641 mL 1.1602 mL
50 mM 0.0371 mL 0.1856 mL 0.3713 mL 0.9281 mL
60 mM 0.0309 mL 0.1547 mL 0.3094 mL 0.7735 mL
80 mM 0.0232 mL 0.1160 mL 0.2320 mL 0.5801 mL
100 mM 0.0186 mL 0.0928 mL 0.1856 mL 0.4641 mL
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Azido-PEG5-triethoxysilane Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Azido-PEG5-triethoxysilanePROTAC LinkersInhibitorinhibitorinhibit

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