Azido-PEG5-triethoxysilane
Based on 1 Customer Validation
Azido-PEG5-triethoxysilane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG5-triethoxysilane is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
For research use only. We do not sell to patients.
- Purity: 95.0%
- Formula: C22H46N4O9Si
- Molecular Weight:538.71
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Storage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
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PEGs |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Liquid
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Molecular Weight 538.71
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Formula C22H46N4O9Si
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Color Colorless to light yellow
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SMILES
O=C(NCCC[Si](OCC)(OCC)OCC)CCOCCOCCOCCOCCOCCN=[N+]=[N-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 250 mg/mL (464.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (266 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8563 mL | 9.2814 mL | 18.5629 mL | 46.4072 mL |
| 5 mM | 0.3713 mL | 1.8563 mL | 3.7126 mL | 9.2814 mL | |
| 10 mM | 0.1856 mL | 0.9281 mL | 1.8563 mL | 4.6407 mL | |
| 15 mM | 0.1238 mL | 0.6188 mL | 1.2375 mL | 3.0938 mL | |
| 20 mM | 0.0928 mL | 0.4641 mL | 0.9281 mL | 2.3204 mL | |
| 25 mM | 0.0743 mL | 0.3713 mL | 0.7425 mL | 1.8563 mL | |
| 30 mM | 0.0619 mL | 0.3094 mL | 0.6188 mL | 1.5469 mL | |
| 40 mM | 0.0464 mL | 0.2320 mL | 0.4641 mL | 1.1602 mL | |
| 50 mM | 0.0371 mL | 0.1856 mL | 0.3713 mL | 0.9281 mL | |
| 60 mM | 0.0309 mL | 0.1547 mL | 0.3094 mL | 0.7735 mL | |
| 80 mM | 0.0232 mL | 0.1160 mL | 0.2320 mL | 0.5801 mL | |
| 100 mM | 0.0186 mL | 0.0928 mL | 0.1856 mL | 0.4641 mL |
Azido-PEG5-triethoxysilane Related Classifications
HY-140856 Related Classifications
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