2. PROTAC
  3. PROTAC Linkers
  4. Biotinyl-NH-PEG3-C3-amido-C3-COOH

Biotinyl-NH-PEG3-C3-amido-C3-COOH 

Cat. No.: HY-130142A Purity: 99.91%
COA Handling Instructions

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Biotinyl-NH-PEG3-C3-amido-C3-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Biotinyl-NH-PEG3-C3-amido-C3-COOH Chemical Structure

Biotinyl-NH-PEG3-C3-amido-C3-COOH Chemical Structure

CAS No. : 1202761-21-4

Size Price Stock Quantity
50 mg USD 114 In-stock
100 mg USD 180 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of Biotinyl-NH-PEG3-C3-amido-C3-COOH:

Biotinyl-NH-PEG3-C3-amido-C3-COOH Related Antibodies

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Description

Biotinyl-NH-PEG3-C3-amido-C3-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Biotinyl-NH-PEG3-C3-amido-C3-COOH Related Antibodies
Molecular Weight

560.70

Formula

C25H44N4O8S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(CCCC(NCCCOCCOCCOCCCNC(CCCC[C@H]1[C@]2([H])[C@](NC(N2)=O)([H])CS1)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (445.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7835 mL 8.9174 mL 17.8348 mL
5 mM 0.3567 mL 1.7835 mL 3.5670 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.91%

COA (241 KB) HNMR (241 KB) LCMS (88 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7835 mL 8.9174 mL 17.8348 mL 44.5871 mL
5 mM 0.3567 mL 1.7835 mL 3.5670 mL 8.9174 mL
10 mM 0.1783 mL 0.8917 mL 1.7835 mL 4.4587 mL
15 mM 0.1189 mL 0.5945 mL 1.1890 mL 2.9725 mL
20 mM 0.0892 mL 0.4459 mL 0.8917 mL 2.2294 mL
25 mM 0.0713 mL 0.3567 mL 0.7134 mL 1.7835 mL
30 mM 0.0594 mL 0.2972 mL 0.5945 mL 1.4862 mL
40 mM 0.0446 mL 0.2229 mL 0.4459 mL 1.1147 mL
50 mM 0.0357 mL 0.1783 mL 0.3567 mL 0.8917 mL
60 mM 0.0297 mL 0.1486 mL 0.2972 mL 0.7431 mL
80 mM 0.0223 mL 0.1115 mL 0.2229 mL 0.5573 mL
100 mM 0.0178 mL 0.0892 mL 0.1783 mL 0.4459 mL
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Biotinyl-NH-PEG3-C3-amido-C3-COOH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Biotinyl-NH-PEG3-C3-amido-C3-COOH1202761-21-4PROTAC LinkersInhibitorinhibitorinhibit

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