CAPN15 - calpain 15 Gene

Also Known as OGIN; SOLH

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6650

About CAPN15

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:527,712-554,636 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 236 orthologues, 20 paralogues and is associated with 1 phenotype. Broad expression in colon (RPKM 5.1), spleen (RPKM 4.7) and 25 other tissues.

Summary

This gene encodes a protein containing zinc-finger-like repeats and a calpain-like protease domain. The encoded protein may function as a transcription factor, RNA-binding protein, or in protein-protein interactions during visual system development. [provided by RefSeq, Jul 2008]

CAPN15 Products (1)

mRNA	Protein	Name
NM_005632.3	NP_005623.1	calpain-15

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAPN15 Protein Structure

zf-RanBP

Peptidase_C2

0
200
400
600
800
1000
1086 a.a.

Protein Preferred Names	Protein Names
calpain-15	small optic lobes homolog

CAPN15 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CAPN15	O75808	TRAF2	Homo sapiens	Q12933	Validated Y2H	32296183
Intra	CAPN15	O75808	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	CAPN15	O75808	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	CAPN15	O75808	RNF216	Homo sapiens	Q9NWF9	Y2H Array	32296183
Intra	CAPN15	O75808	RNF216	Homo sapiens	Q9NWF9	Y2H Prey Pooling	32296183
Intra	CAPN15	O75808	RNF216	Homo sapiens	Q9NWF9	Validated Y2H	32296183
Intra	CAPN15	O75808	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
Intra	CAPN15	O75808	DAZAP2	Homo sapiens	Q15038	Validated Y2H	32296183
Intra	CAPN15	O75808	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	CAPN15	O75808	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	CAPN15	O75808	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	CAPN15	O75808	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Oculogastrointestinal Neurodevelopmental Syndrome	OGIN Oculogastrointestinal-Neurodevelopmental Syndrome Ogin Syndrome
Coloboma, Ocular, Autosomal Dominant	Coloboma, Ocular Coloboma Of Iris, Choroid, And Retina Coi Coloboma, Uveoretinal COAD Ocular Coloboma Uveoretinal Coloboma Chronic Obstructive Airway Disease
Coloboma Of Macula	Coloboma Congenital Ocular Coloboma Microphthalmia, Isolated, With Coloboma Agenesis Of Macula Hereditary Macular Coloboma Ocular Coloboma Coloboma Of Eye Macular Coloboma Uveoretinal Coloboma
Spastic Hemiplegia	Spastic Hemiplegic Cerebral Palsy Hemiplegic Cerebral Palsy Congenital Hemiplegia Hemiplegic Infantile Cerebral Palsy Cerebral Palsy Spastic Hemiplegic Spastic Hemiplegia Cerebral Palsy Hemiplegia, Spastic
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Microphthalmia	Microphthalmos Isolated Anophthalmia-Microphthalmia Syndrome Isolated Microphthalmia-Anophthalmia-Coloboma Simple Microphthalmos Clinical Anophthalmia Isolated Anophthalmia - Microphthalmia Isolated Pure Microphthalmia Mac Spectrum Microphthalmia-Anophthalmia-Coloboma Spectrum Primitive Anophthalmia Globe Of Eye Small Small Eyeball Hypoplasia Of Eye Isolated Nanophthalmos Rudimentary Eye Dysplasia Of Eye
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Focal Hand Dystonia	Organic Writer'S Cramp Dystonia, Focal, Task-Specific
Spastic Cerebral Palsy	Palsy, Cerebral, Spastic Infantile Hemiplegia Nos Postnatal Infantile Hemiplegia Nos Congenital Spastic Hemiplegia Spastic Hemiplegic Cerebral Palsy Congenital Hemiplegia Nos Hemiplegic Cerebral Palsy Hemiplegic Infantile Cerebral Palsy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01888	CAPN15 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CAPN15	VGNC	VGNC:26746
Macaca mulatta	CAPN15	VGNC	VGNC:70470
Mus musculus	CAPN15	MGD	MGI:1355075
Canis familiaris	CAPN15	VGNC	VGNC:38703
Rattus norvegicus	CAPN15	RGD	RGD:1306514
Felis catus	CAPN15	VGNC	VGNC:60353
Others	CAPN15	NCBI