COG7 - component of oligomeric golgi complex 7 Gene

Also Known as CDG2E

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 91949

About COG7

Cytogenetic location: 16p12.2 Genomic coordinates (GRCh38): 16:23,388,493-23,453,189 (from NCBI)

This gene has 6 transcripts (splice variants), 209 orthologues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 7.2), prostate (RPKM 6.0) and 25 other tissues.

Summary

The protein encoded by this gene resides in the golgi, and constitutes one of the 8 subunits of the conserved oligomeric Golgi (COG) complex, which is required for normal golgi morphology and localization. Mutations in this gene are associated with the congenital disorder of glycosylation type IIe.[provided by RefSeq, May 2010]

COG7 Products (1)

mRNA	Protein	Name
NM_153603.4	NP_705831.1	conserved oligomeric Golgi complex subunit 7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15047703	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	27066481	GOA
involved in glycosylation	IMP IMP: Inferred from mutant phenotype	27066481	GOA
involved in intracellular protein transport	IMP IMP: Inferred from mutant phenotype	15107842	GOA
involved in protein glycosylation	IMP IMP: Inferred from mutant phenotype	15107842	GOA
involved in protein localization to Golgi apparatus	IMP IMP: Inferred from mutant phenotype	16510524	GOA
involved in protein localization to organelle	IMP IMP: Inferred from mutant phenotype	16420527	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	16420527	GOA
involved in retrograde transport, vesicle recycling within Golgi	IMP IMP: Inferred from mutant phenotype	27066481	GOA
involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	16420527	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	11980916	GOA
part of Golgi transport complex	IDA IDA: Inferred from direct assay	15047703	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COG7 Protein Structure

COG7

0
200
400
600
770 a.a.

Protein Preferred Names	Protein Names
conserved oligomeric Golgi complex subunit 7	COG complex subunit 7

COG7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	COG7	P83436	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Array	32296183
Intra	COG7	P83436	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Prey Pooling	26871637
Intra	COG7	P83436	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Prey Pooling	32296183
Intra	COG7	P83436	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	26871637
Intra	COG7	P83436	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	COG7	P83436	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Array	26871637
Intra	COG7	P83436	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	26871637
Intra	COG7	P83436	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	26871637
Intra	COG7	P83436	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	26871637
Intra	COG7	P83436	COG4	Homo sapiens	Q9H9E3	CoIP	15047703
Intra	COG7	P83436	COG4	Homo sapiens	Q9H9E3	Anti Bait CoIP	19536132
Intra	COG7	P83436	COG4	Homo sapiens	Q9H9E3	Anti Tag CoIP	33961781
Intra	COG7	P83436	COG5	Homo sapiens	Q9UP83	CoIP	15047703
Intra	COG7	P83436	COG5	Homo sapiens	Q9UP83	Anti Tag CoIP	33961781
Intra	COG7	P83436	TAX1BP1	Homo sapiens	Q86VP1	Y2H Array	32296183
Intra	COG7	P83436	TAX1BP1	Homo sapiens	Q86VP1	Validated Y2H	26871637
Intra	COG7	P83436	TAX1BP1	Homo sapiens	Q86VP1	Y2H Array	26871637
Intra	COG7	P83436	TAX1BP1	Homo sapiens	Q86VP1	Validated Y2H	25416956
Intra	COG7	P83436	TAX1BP1	Homo sapiens	Q86VP1	Validated Y2H	32296183
Intra	COG7	P83436	TAX1BP1	Homo sapiens	Q86VP1	Y2H Prey Pooling	26871637
Intra	COG7	P83436	TAX1BP1	Homo sapiens	Q86VP1	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Immunodeficiency 47	Congenital Disorder Of Glycosylation Type Ii CDG2E Congenital Disorder Of Glycosylation Type Iie IMD47 Cdg2s Cdg Iis Cdgiis Immunodeficiency And Hepatopathy With Or Without Neurologic Features Congenital Disorder Of Glycosylation, Type Ii CDG1I Congenital Disorder Of Glycosylation, Type Iie Cdg Iie Congenital Disorder Of Glycosylation Type 2e Congenital Disorder Of Glycosylation, Type Iis Cdg Ii Cdgii Cdgiie Carbohydrate Deficient Glycoprotein Syndrome Type Iie Cdg Syndrome Type Iie Congenital Disorder Of Glycosylation Ii Congenital Disorder Of Glycosylation 1i Cdg-Iie Alg2-Cdg Cdg-Ii Glycosylation, Congenital Disorder Of, Type Ii Cdgiide Congenital Disorder Of Glycosylation Type Iis Cog7-Cdg Cdg Syndrome Type Ii Carbohydrate Deficient Glycoprotein Syndrome Type Ii Congenital Disorder Of Glycosylation Type 1i Mannosyltransferase 2 Deficiency Congenital Disorder Of Glycosylation 2e Congenital Disorder Of Glycosylation 2s Congenital Disorders Of Glycosylation Type Ii Glycosylation, Congenital Disorder Of, Type Iie Immunodeficiency, Type 47 Congenital Disorder Of Glycosylation Type 2a
Congenital Disorder Of Glycosylation, Type Iih	CDG2H Congenital Disorder Of Glycosylation Type Iih Cdg Iih Cdgiih Carbohydrate Deficient Glycoprotein Syndrome Type Iih Congenital Disorder Of Glycosylation Type 2h Cog8-Cdg Cdg-Iih Cdgiidh Cdg Syndrome Type Iih Congenital Disorder Of Glycosylation 2h Glycosylation, Congenital Disorder Of, Type Iih
Congenital Disorder Of Glycosylation, Type Iij	CDG2J Congenital Disorder Of Glycosylation Type Iij Cdg Iij Cdgiij Carbohydrate Deficient Glycoprotein Syndrome Type Iij Cdg Syndrome Type Iij Congenital Disorder Of Glycosylation Type 2j Cog4-Cdg Cdg-Iij Cdgiidj Congenital Disorder Of Glycosylation 2j Glycosylation, Congenital Disorder Of, Type Iij
Congenital Disorder Of Glycosylation, Type Iii	CDG2I Congenital Disorder Of Glycosylation Type Iii Cdgiii Carbohydrate Deficient Glycoprotein Syndrome Type Iii Congenital Disorder Of Glycosylation Type 2i Cog5-Cdg Cdgiidi Congenital Disorder Of Glycosylation 2i Glycosylation, Congenital Disorder Of, Type Iii Congenital Disorder Of Glycosylation, Type I-Iix
Congenital Disorder Of Glycosylation, Type Iil	CDG2L Congenital Disorder Of Glycosylation Type Iil Cdg Iil Cog6-Cgd Cdgiil Cdg Syndrome Type Iil Congenital Disorder Of Glycosylation Type 2l Cdg-Iil Cdgiidl Congenital Disorder Of Glycosylation 2l Glycosylation, Congenital Disorder Of, Type Iil
White-Sutton Syndrome	WHSUS Mrd37 Intellectual Disability-Microcephaly-Strabismus-Behavioral Abnormalities Syndrome Mental Retardation, Autosomal Dominant 37 Autosomal Dominant Mental Retardation 37 Pogz-Related Intellectual Disability Syndrome
Saul-Wilson Syndrome	Microcephalic Osteodysplastic Dysplasia Microcephalic Osteodysplastic Dysplasia, Saul-Wilson Type SWILS Microcephalic Osteodysplastic Dysplasia Saul Wilson Type
Geroderma Osteodysplasticum	Gerodermia Osteodysplastica Geroderma Osteodysplastica GO Walt Disney Dwarfism Type Of Gerodermia Osteodysplastica
Congenital Disorder Of Glycosylation, Type In	Congenital Disorder Of Glycosylation CDG1N Congenital Disorders Of Glycosylation Cdg In Cdgin Congenital Disorder Of Glycosylation 1n Carbohydrate-Deficient Glycoprotein Syndrome Cdg Rft1-Cdg Cdg-In Congenital Disorder Of Glycosylation Type In Carbohydrate Deficient Glycoprotein Syndrome Cdg Syndrome Congenital Disorder Of Glycosylation In Carbohydrate-Deficient Glycoprotein Syndromes Cdg Syndrome Type In Carbohydrate Deficient Glycoprotein Syndrome Type In Congenital Disorder Of Glycosylation Type 1n Man5glcnac2-Pp-Dol Flippase Deficiency Glycosylation, Congenital Disorder Of Glycosylation, Congenital Disorder Of, Type In
Granulomatous Disease, Chronic, X-Linked	CGDX Chronic Granulomatous Disease, X-Linked X-Linked Chronic Granulomatous Disease Cgd Cytochrome B-Negative Granulomatous Disease, Chronic, X-Linked Cdgx X-Linked Chronic Cytochrome B-Negative Granulomatous Disease Chronic Granulomatous Disease Cytochrome B-Negative X-Linked Chronic Granulomatous Disease Cytochrome B-Positive X-Linked Granulomatous Disease, Chronic, X-Linked, Variant
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02956	COG7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-117192	NSC145366 monohydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	COG7	MGD	MGI:2685013
Felis catus	COG7	VGNC	VGNC:61050
Rattus norvegicus	COG7	RGD	RGD:1566058
Macaca mulatta	COG7	VGNC	VGNC:71208
Bos taurus	COG7	VGNC	VGNC:27551
Canis familiaris	COG7	VGNC	VGNC:39453
Others	COG7	NCBI