BMS-688521 (Standard)
BMS-688521 (Standard) is the analytical standard of BMS-688521 (HY-10596). This product is intended for research and analytical applications. BMS-688521 is a highly potent, orally active inhibitor of the LFA-1/ICAM interaction, with an IC50 of 2.5 nM in the adhesion assay and an IC50 of 60 nM in the MLR assay. BMS-688521 is efficacious in a mouse allergic eosinophilic lung inflammation model.
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- CAS No.: 893397-44-9
- Formule: C26H19Cl2N5O4
- Masse moléculaire:536.37
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Pureté et documentation
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Help & FAQs
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HY-110117
BIRT 377LFA-1 Inhibitor -
HY-19344
LifitegrastLFA-1/ICAM-1 Antagonist -
HY-100506
GLPG0187Integrin Receptor Antagonist -
HY-107587
A-286982LFA-1/ICAM-1 Interaction Inhibitor -
HY-14571
E7820Angiogenesis Inhibitor -
HY-10596
BMS-688521LFA-1/ICAM Interaction Inhibitor -
HY-18644
CWHM-12αV Integrins Inhibitor -
HY-13535A
ATN-161 trifluoroacetate saltIntegrin Antagonist -
HY-15770
TR-14035α4β7/α4β1 Antagonist -
HY-14951
FirategrastIntegrin Antagonist -
HY-13535
ATN-161α5β1/αvβ3 Integrin Binder -
HY-P0023
Cyclo(-RGDfK)αvβ3 Integrin Inhibitor
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 893397-44-9
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Masse moléculaire 536.37
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Formule C26H19Cl2N5O4
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SMILES
ClC1=CC(Cl)=CC(N(C(N(C)[C@]23[C@H](C4=CC=C(C#N)C=C4)CN(C5=NC=C(C(O)=O)C=C5)C3)=O)C2=O)=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Watterson SH, et al. Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic acid (BMS-688521). J Med Chem. 2010 May 13;53(9):3814-30. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BMS-688521 (Standard) Related Classifications
HY-10596R Related Classifications
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