1673590-38-9
1673590-38-9
Chemical Structure
PPARα/δ antagonist-1
- CAS No.: 1673590-38-9
- Formula:C34H29F4N3O4
- Molecular Weight:619.61
InChIKey: YIUSVSPYCXFTHR-UHFFFAOYSA-N
SMILES: O=C(CC1=C(OCC)C=CC(C2=CC=C(CCCC3=NN(C4=CC=C(C(F)(F)F)C=C4)C(N3C5=C(F)C=CC=C5)=O)C=C2)=C1)O
Biological Activity: PPARα/δ antagonist-1 is an orally active, highly selective dual antagonist of PPARα/δ, with IC50 values of 0.113 μM and 0.025 μM against human PPARα and PPARδ, respectively. PPARα/δ antagonist-1 exhibits an excellent in vitro activity profile and preliminary efficacy in mouse tumor models. PPARα/δ antagonist-1 can be used in studies related to cancers (melanoma metastasis, ovarian cancer)[1].
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PPARα/δ antagonist-1 | PPARα/δ antagonist-1 is an orally active, highly selective dual antagonist of PPARα/δ, with IC50 values of 0.113 μM and 0.025 μM against human PPARα and PPARδ, respectively. PPARα/δ antagonist-1 exhibits an excellent in vitro activity profile and preliminary efficacy in mouse tumor models. PPARα/δ antagonist-1 can be used in studies related to cancers (melanoma metastasis, ovarian cancer). | |||||||||||||||||||||
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