CDYL-IN-1
Based on 1 Customer Validation
CDYL-IN-1 is a selective small-molecule inhibitor of CDYL with a KD value of 0.5 μM. CDYL-IN-1 improves renal dysfunction, pathological damage and renal tubular pyroptosis, inhibits FABP4-mediated ROS production, and alleviates renal tubular epithelial cell injury. CDYL-IN-1 is applicable to the research of acute kidney injury.
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- Pureté: 99.80%
- CAS No.: 2378625-66-0
- Formule: C18H23N3O3
- Masse moléculaire:329.39
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Stockage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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CDYL 0.5 μM (Kd) |
CDYL-IN-1 (D03) is non-toxic to TCMK-1 mouse renal tubular epithelial cells[1].
CDYL-IN-1 (D03) (100 μM; 12 h) alleviates injury and pyroptosis in cisplatin (HY-17394)-stimulated TCMK-1 mouse renal tubular epithelial cells by reducing CDYL expression[1].
CDYL-IN-1 (D03) (100 μM; 12 h) suppresses FABP4 expression in cisplatin-stimulated TCMK-1 mouse renal tubular epithelial cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wild-type; FABP4 knockout (KO)[1]
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Dosage:2.5 mg/kg/d
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Administration:i.p.; daily; 6 days (3 days pre-cisplatin, 3 days post-cisplatin)
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Result:Reduced cisplatin-induced increases in kidney CDYL mRNA and protein levels.
Alleviated renal tissue damage observed via H&E staining.
Reduced serum creatinine levels.
Lowered mRNA levels of kidney injury markers NGAL and KIM-1.
Suppressed pyroptosis as shown by reduced mRNA levels of NLRP3 and GSDMD, and reduced protein levels of NLRP3, GSDMD-N, cleaved caspase 1, and cleaved IL-1β.
Detected no observable side effects on liver or kidney function, or in heart, liver, lung, or spleen tissues.
Chemical Information
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CAS No. 2378625-66-0
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Appearance Solid
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Masse moléculaire 329.39
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Formule C18H23N3O3
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Color White to off-white
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SMILES
O=C1N(CC(N2CCC(N3CCCC3)CC2)=O)C4=CC=CC=C4O1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvant et solubilité
DMSO : 20 mg/mL (60.72 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0359 mL | 15.1796 mL | 30.3591 mL | 75.8979 mL |
| 5 mM | 0.6072 mL | 3.0359 mL | 6.0718 mL | 15.1796 mL | |
| 10 mM | 0.3036 mL | 1.5180 mL | 3.0359 mL | 7.5898 mL | |
| 15 mM | 0.2024 mL | 1.0120 mL | 2.0239 mL | 5.0599 mL | |
| 20 mM | 0.1518 mL | 0.7590 mL | 1.5180 mL | 3.7949 mL | |
| 25 mM | 0.1214 mL | 0.6072 mL | 1.2144 mL | 3.0359 mL | |
| 30 mM | 0.1012 mL | 0.5060 mL | 1.0120 mL | 2.5299 mL | |
| 40 mM | 0.0759 mL | 0.3795 mL | 0.7590 mL | 1.8974 mL | |
| 50 mM | 0.0607 mL | 0.3036 mL | 0.6072 mL | 1.5180 mL | |
| 60 mM | 0.0506 mL | 0.2530 mL | 0.5060 mL | 1.2650 mL |
CDYL-IN-1 Related Classifications
HY-161904 Related Classifications
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