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Cat. No.: HY-187640

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CRM-51005

CRM-51005 is a phospholipase C (PLC)γ1 inhibitor with a bovine IC₅₀ of 13.0 μg/mL. CRM-51005 inhibits PLCγ1 enzymatic activity and platelet-derived growth factor-induced phosphoinositide turnover. CRM-51005 acts as a cell growth inhibitor via suppression of PLC, phosphoinositide turnover, DNA synthesis, and cell proliferation.

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CAS No.: 203051-01-8
Formule: C₁₅H₂₀O₃
Masse moléculaire:248.32

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CRM-51005 Chemical Structure

CAS No.: 203051-01-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target

^[1]

PLCγ1

13 μg/mL (IC₅₀)

Voir tous les produits spécifiques à Isoform Phospholipase :

Cellular Effect

Cell Line	Type	Value	Description	References
NIH3T3	IC50	0.8 μg/mL	Inhibition of PDGF-induced total inositol phosphates formation in NIH3T3γ1 cells; cells were prelabelled with myo-[2-³H]-inositol for 24 hours, preincubated in 20 mM LiCl for 15 minutes, treated with CRM-51005 for 10 minutes, then stimulated with PDGF for 30 minutes, with IPₜ extracted and measured via Biorad AG 1-X8 anion exchange column. Inhibition of PDGF-induced total inositol phosphates formation in NIH3T3γ1 cells; cells were prelabelled with myo-[2-³H]-inositol for 24 hours, preincubated in 20 mM LiCl for 15 minutes, treated with CRM-51005 for 10 minutes, then stimulated with PDGF for 30 minutes, with IPₜ extracted and measured via Biorad AG 1-X8 anion exchange column.	9510921

In Vitro

CRM-51005 inhibits purified bovine cerebellum PLCγ1 enzyme activity with an IC₅₀ of 13.0 μg/mL^[1].
CRM-51005 (10 min) inhibits PDGF-induced total inositol phosphates formation in NIH3T3γ1 cells with an IC₅₀ of 0.8 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 203051-01-8
Masse moléculaire 248.32
Formule C₁₅H₂₀O₃
SMILES

CCC/C=C(C1=C(C(O)=C(C(O)=C1)CC)C=O)\C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Oh WK, et al. CRM-51005, a new phospholipase C inhibitor produced by unidentified fungal strain MT51005. J Antibiot (Tokyo). 1997 Dec;50(12):1083-5.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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