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United States

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Cat. No.: HY-172923

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FGFR-IN-20

Glu-IN-1 (compound AF1) is a covalent and selective FGFR2 inhibitor with an IC₅₀ of 1.6 μM. Glu-IN-1 covalently modifies Glu489 in FGFR2.

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Formule: C₃₆H₄₃N₅O₃
Masse moléculaire:593.76

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

FGFR-IN-20 Chemical Structure

Stock

Quantité

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

Glu-IN-1 (compound AF1) is a covalent and selective FGFR2 inhibitor with an IC₅₀ of 1.6 μM. Glu-IN-1 covalently modifies Glu489 in FGFR2^[1].

Chemical Information

Masse moléculaire 593.76
Formule C₃₆H₄₃N₅O₃
SMILES

CNC(C1=CC=C2C(N=C(N2CCCCCCCCCCNC(C3N=C3C4=CC=CC=C4)=O)C5=CC(C)=C(C(C)=C5)O)=C1)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Wu X, et al. Residue-Selective Inhibitors Discovery via Covalent DNA-Encoded Chemical Libraries with Diverse Warheads. J Am Chem Soc. 2025 May 7;147(18):15469-15481. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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