FXR agonist 15
FXR agonist 15 is a selective, potent and orally active farnesoid X receptor (FXR) agonist with EC50 of 0.76 μM. FXR agonist 15 exhibits no obvious activation on other nuclear receptors including LXRα/β, PXR, PPARα/β/γ, THR-β, with EC50 values all >10 μM. FXR agonist 15 can alleviate steatosis, lobular inflammation, hepatocyte ballooning and liver fibrosis. FXR agonist 15 can be used for the research of nonalcoholic steatohepatitis (NASH).
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- CAS No.: 2991276-14-1
- Formule: C24H22Cl2FNO5S
- Masse moléculaire:526.40
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Help & FAQs
Activité biologique
Description
In Vivo
FXR agonist 15 (500 mg/kg, p.o., once daily for 10 days) causes no mouse death or abnormal behavior, shows no significant abnormalities in serum liver and kidney function indices (AST, ALT, ALP, creatinine, urea) and blood lipid indices (TG, TC), exhibits no acute toxic damage to major organs, and has good safety in ICR mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:WD + CCl4-induced mice NASH models (C57BL/6, 8 weeks)[1]
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Dosage:20 mg/kg
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Administration:Orally gavage, per day for 4 weeks
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Result:Reduced hepatic lipid droplets, NAFLD activity score (NAS), and levels of triacylglycerol (TG) and total cholesterol (TC).
Decreased fibrotic markers (α-SMA, hydroxyproline) and activated the FXR pathway.
Upregulated SHP, BSEP, and OSTβ, while downregulated CYP7A1.
Chemical Information
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CAS No. 2991276-14-1
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Masse moléculaire 526.40
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Formule C24H22Cl2FNO5S
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SMILES
FC1=CC(C2=CC=C(N(S(=O)(C3=C(Cl)C=CC=C3Cl)=O)CC(C)C)C=C2)=CC=C1OCC(O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FXR agonist 15 Related Classifications
HY-179703 Related Classifications
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