RBM45 - RNA binding motif protein 45 Gene

Also Known as DRB1; RB-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 129831

About RBM45

Cytogenetic location: 2q31.2 Genomic coordinates (GRCh38): 2:178,112,437-178,139,011 (from NCBI)

This gene has 7 transcripts (splice variants), 207 orthologues and 24 paralogues. Ubiquitous expression in testis (RPKM 3.5), lymph node (RPKM 3.4) and 25 other tissues.

Summary

This gene encodes a member of the RNA recognition motif (RRM)-type RNA-binding family of proteins. This protein exhibits preferential binding to poly(C) RNA. Initial cloning of this gene found that the rat ortholog was dynamically expressed in the developing rat brain. This protein has been localized to inclusion bodies in the brain and spinal cord of amyotrophic lateral sclerosis and Alzheimer's patients. A pseudogene has been identified on chromosome 8. [provided by RefSeq, Feb 2015]

RBM45 Products (3)

mRNA Protein Name
NM_001365578.1 NP_001352507.1 RNA-binding protein 45 isoform 1
NM_001365579.1 NP_001352508.1 RNA-binding protein 45 isoform 2
NM_152945.4 NP_694453.2 RNA-binding protein 45 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables RNA binding IDA
IDA: Inferred from direct assay
12220514 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Cellular Component GO Annotation Evidence Références Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12220514 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12220514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBM45 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (34 - 92)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (127 - 183)

RRM_5

RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (409 - 458)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 474 a.a.
Protein Preferred Names Protein Names

RNA-binding protein 45

  • developmentally regulated RNA-binding protein 1

RBM45 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
RBM45 Q8IUH3 MEMO1 Homo sapiens Q9Y316
Y2H Array
25416956
Intra
RBM45 Q8IUH3 MEMO1 Homo sapiens Q9Y316
Y2H Prey Pooling
25416956
Intra
RBM45 Q8IUH3 FANCL Homo sapiens Q9NW38
Y2H Prey Pooling
25416956
Intra
RBM45 Q8IUH3 TXN2 Homo sapiens Q99757
Y2H Prey Pooling
25416956
Intra
RBM45 Q8IUH3 MATR3 Homo sapiens P43243
IF
26979993
Intra
RBM45 Q8IUH3 MATR3 Homo sapiens P43243
Anti Tag CoIP
26979993
Intra
RBM45 Q8IUH3 MATR3 Homo sapiens P43243
Crosslink
26979993
Intra
RBM45 Q8IUH3 HNRNPA1 Homo sapiens P09651
Anti Tag CoIP
26979993
Intra
RBM45 Q8IUH3 HNRNPA1 Homo sapiens P09651
Crosslink
26979993
Intra
RBM45 Q8IUH3 HNRNPA1 Homo sapiens P09651
IF
26979993
Intra
RBM45 Q8IUH3 TRAF1 Homo sapiens Q13077
Y2H Array
25416956
Intra
RBM45 Q8IUH3 HNRNPL Homo sapiens P14866
Crosslink
26979993
Intra
RBM45 Q8IUH3 HNRNPL Homo sapiens P14866
Anti Tag CoIP
26979993
Intra
RBM45 Q8IUH3 HNRNPL Homo sapiens P14866
IF
26979993
Intra
RBM45 Q8IUH3 RBM14 Homo sapiens Q96PK6
Anti Tag CoIP
26979993
Intra
RBM45 Q8IUH3 RBM14 Homo sapiens Q96PK6
Crosslink
26979993
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Frontotemporal Dementia

  • Pallidopontonigral Degeneration

  • Frontotemporal Lobar Degeneration

  • Semantic Dementia

  • FTD

  • Frontotemporal Lobe Dementia

  • Multiple System Tauopathy With Presenile Dementia

  • Dementia, Frontotemporal

  • Frontotemporal Dementia With Parkinsonism

  • Mstd

  • Frontotemporal Lobar Degeneration With Tau Inclusions

  • Ftld With Tau Inclusions

  • Dementia, Frontotemporal, With Parkinsonism

  • Fldem

  • Ftdp17

  • Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

  • Ddpac

  • Wilhelmsen-Lynch Disease

  • Wld

  • Ppnd

  • Dementia, Frontotemporal, With Or Without Parkinsonism

  • Semantic Primary Progressive Aphasia

  • Semantic Variant Ppa

  • Wilhemsen-Lynch Disease

  • Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

  • Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

  • Ftd-Als

  • Ftld

  • Pick Complex

  • Pick Disease Of The Brain

  • Frontotemporal Dementia With Parkinsonism-17

  • Grn-Related Frontotemporal Dementia

  • Frontotemporal Dementia With Motor Neuron Disease

  • Dementia In Fronto-Temporal Lobar Degeneration

  • Ftd - [Frontotemporal Dementia]

  • Temple Dementia

  • Frontal Lobe Dementia
Tick Infestation

  • Tick Infestations
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-122054 BPK-29 99.4% Unkown
HY-122054A BPK-29 hydrochloride Inhibitor 99.19% Unkown
HY-RS11754 RBM45 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus RBM45 VGNC VGNC:52814
Felis catus RBM45 VGNC VGNC:64533
Mus musculus RBM45 MGD MGI:2387367
Canis familiaris RBM45 VGNC VGNC:53104
Macaca mulatta RBM45 VGNC VGNC:76527
Rattus norvegicus RBM45 RGD RGD:628862
Others RBM45 NCBI