Lrp2 - low density lipoprotein receptor-related protein 2 Gene

Also Known as Gp330; Megalin; b2b1625.2Clo; D230004K18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14725

Summary

Predicted to enable several functions, including PDZ domain binding activity; chaperone binding activity; and insulin-like growth factor I binding activity. Involved in several processes, including circulatory system development; nervous system development; and reproductive structure development. Acts upstream of or within several processes, including animal organ development; circulatory system development; and vitamin metabolic process. Located in several cellular components, including brush border membrane; clathrin-coated pit; and cytoplasmic vesicle. Is expressed in several structures, including egg cylinder; heart and pericardium; metanephros; ureter; and ventricular layer. Used to study Donnai-Barrow syndrome; Fanconi syndrome; and degenerative myopia. Human ortholog(s) of this gene implicated in Donnai-Barrow syndrome and autoimmune thyroiditis. Orthologous to human LRP2 (LDL receptor related protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Lrp2 Products (1)

mRNA Protein Name
NM_001081088.2 NP_001074557.1 low-density lipoprotein receptor-related protein 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
10772929 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of or within aorta development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within cell population proliferation IMP
IMP: Inferred from mutant phenotype
15623804 MGI
involved in coronary artery morphogenesis IMP
IMP: Inferred from mutant phenotype
26822476 MGI
acts upstream of or within coronary vasculature development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within cranial skeletal system development IMP
IMP: Inferred from mutant phenotype
34463328 MGI
acts upstream of or within diol metabolic process IMP
IMP: Inferred from mutant phenotype
10052453 MGI
involved in folate import across plasma membrane IMP
IMP: Inferred from mutant phenotype
24639464 MGI
acts upstream of or within forebrain development IMP
IMP: Inferred from mutant phenotype
15623804 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
34463328 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
27002738 MGI
involved in male gonad development IMP
IMP: Inferred from mutant phenotype
16143106 MGI
involved in negative regulation of BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
20460439 MGI
involved in neural tube closure IMP
IMP: Inferred from mutant phenotype
24639464 MGI
involved in neuron projection arborization IMP
IMP: Inferred from mutant phenotype
20637285 MGI
acts upstream of or within outflow tract morphogenesis IMP
IMP: Inferred from mutant phenotype
34463328 MGI
involved in outflow tract septum morphogenesis IMP
IMP: Inferred from mutant phenotype
26822476 MGI
involved in positive regulation of neurogenesis IMP
IMP: Inferred from mutant phenotype
20460439 MGI
involved in positive regulation of oligodendrocyte progenitor proliferation IMP
IMP: Inferred from mutant phenotype
22354480 MGI
involved in protein transport IDA
IDA: Inferred from direct assay
17324488 MGI
involved in pulmonary artery morphogenesis IMP
IMP: Inferred from mutant phenotype
26822476 MGI
involved in receptor-mediated endocytosis IDA
IDA: Inferred from direct assay
15623804 MGI
acts upstream of or within receptor-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
10052453 MGI
involved in receptor-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
12724130 MGI
involved in response to leptin IDA
IDA: Inferred from direct assay
17324488 MGI
involved in secondary heart field specification IMP
IMP: Inferred from mutant phenotype
26822476 MGI
involved in sensory perception of sound IMP
IMP: Inferred from mutant phenotype
17846082 MGI
involved in vagina development IMP
IMP: Inferred from mutant phenotype
16143106 MGI
involved in ventricular compact myocardium morphogenesis IMP
IMP: Inferred from mutant phenotype
26822476 MGI
acts upstream of or within ventricular septum development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within vitamin D metabolic process IMP
IMP: Inferred from mutant phenotype
10052453 MGI
Cellular Component GO Annotation Evidence Références Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
15616221 MGI
located in apical part of cell IDA
IDA: Inferred from direct assay
15342463 MGI
located in apical plasma membrane IDA
IDA: Inferred from direct assay
15616221 MGI
located in axon IDA
IDA: Inferred from direct assay
20637285 MGI
located in brush border IDA
IDA: Inferred from direct assay
12815097 MGI
located in brush border membrane IDA
IDA: Inferred from direct assay
10662735 MGI
located in clathrin-coated pit IDA
IDA: Inferred from direct assay
15616221 MGI
located in dendrite IDA
IDA: Inferred from direct assay
20637285 MGI
located in endocytic vesicle IDA
IDA: Inferred from direct assay
15616221 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
15616221 MGI
located in endosome IDA
IDA: Inferred from direct assay
10766831 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
16143106 MGI
located in membrane IDA
IDA: Inferred from direct assay
15082773 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16901941 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

low-density lipoprotein receptor-related protein 2

  • glycoprotein 330

Lrp2 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P86698 LRP2 Antibody (YA6390) IHC-P, WB, IF-Tissue, IHC-F, ICC/IF Mouse, Rat, Human
HY-P86698A LRP2 Antibody (YA6390)(PBS only) IHC-P, WB, IF-Tissue, IHC-F, ICC/IF Mouse, Rat, Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS17962 Lrp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24433 Lrp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07797 LRP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lrp2 NCBI NCBI:4036