UBA7 - ubiquitin like modifier activating enzyme 7 Gene

Also Known as D8; UBE2; UBE7; UBA1B; UBE1L

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7318

About UBA7

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:49,805,209-49,813,953 (from NCBI)

This gene has 11 transcripts (splice variants), 264 orthologues and 9 paralogues. Ubiquitous expression in spleen (RPKM 37.8), lymph node (RPKM 34.4) and 25 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and Apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq, Jul 2008]

UBA7 Products (1)

mRNA Protein Name
NM_003335.3 NP_003326.2 ubiquitin-like modifier-activating enzyme 7

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ISG15 activating enzyme activity IDA
IDA: Inferred from direct assay
16428300 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables ubiquitin-protein transferase activity EXP
EXP: Inferred from Experiment
18583345 GOA
Biological Process GO Annotation Evidence References Source
involved in ISG15-protein conjugation IDA
IDA: Inferred from direct assay
16428300 GOA
involved in innate immune response IDA
IDA: Inferred from direct assay
28724761 GOA
involved in protein modification process IDA
IDA: Inferred from direct assay
16428300 GOA
Cellular Component GO Annotation Evidence References Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
29743376 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBA7 Protein Structure

ThiF

ThiF: ThiF family (33 - 158)

ThiF

ThiF: ThiF family (432 - 573)

UBA_e1_thiolCys

UBA_e1_thiolCys: Ubiquitin-activating enzyme active site (577 - 624)

(716 - 765)

(808 - 874)

E1_UFD

E1_UFD: Ubiquitin fold domain (881 - 1006)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1012 a.a.
Protein Preferred Names Protein Names

ubiquitin-like modifier-activating enzyme 7

  • UBA1, ubiquitin-activating enzyme E1 homolog B

UBA7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UBA7 P41226 TARDBP Homo sapiens Q13148
Y2H Pooling
32814053
Intra
UBA7 P41226 TARDBP Homo sapiens Q13148
Validated Y2H
32814053
Intra
UBA7 P41226 TARDBP Homo sapiens Q13148
Y2H Array
32814053
Intra
UBA7 P41226 ISG15 Homo sapiens P05161
Comigration in SDS
17597759
Intra
UBA7 P41226 ISG15 Homo sapiens P05161
Anti Tag CoIP
33961781
Intra
UBA7 P41226 ISG15 Homo sapiens P05161
Y2H Pooling
16189514
Intra
UBA7 P41226 ISG15 Homo sapiens P05161
Validated Y2H
25416956
Intra
UBA7 P41226 ISG15 Homo sapiens P05161
Y2H Array
32296183
Intra
UBA7 P41226 ISG15 Homo sapiens P05161
Y2H Prey Pooling
25416956
Intra
UBA7 P41226 ISG15 Homo sapiens P05161
Y2H Array
25416956
Intra
UBA7 P41226 ISG15 Homo sapiens P05161
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UBA7 Proteins

Cat. No. Product Name Accession Purity
HY-P79454 ISG15 E1/UBE1L Protein, Human (sf9, His, StrepⅡ) P41226 (D2-L1012) ≥ 95%, as determined by reducing SDS-PAGE.

UBA7 Antibodies

Cat. No. Product Name Application Reactivity
HY-P85405 UBE1L Antibody (YA5097) WB; IHC-P; IHC-F; FC; IF-Tissue Human, Mouse, Rat

Related Diseases

Diseases Alias
Acute Promyelocytic Leukemia

  • Leukemia, Acute Promyelocytic

  • Acute Myeloblastic Leukemia Type 3

  • Aml M3

  • APL

  • Leukemia, Acute Promyelocytic, Somatic

  • Aml With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Apml

  • Acute Myeloblastic Leukemia 3

  • Acute Myeloid Leukemia With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Acute Myeloblastic Leukaemia Type 3

  • Acute Myeloid Leukaemia M3

  • Acute Myeloid Leukemia M3

  • Acute Promyelocytic Leukaemia

  • M3 Anll

  • Myeloid Leukemia, Acute, M3

  • Leukemia Promyelocytic Acute

  • Leukemia, Promyelocytic, Acute

  • Leukemia, Acute, Promyelocytic
Vexas Syndrome

  • VEXAS

  • Vexas Syndrome, Somatic

  • Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory And Somatic Syndrome

  • Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory, Somatic Syndrome

  • Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory, Somatic
Influenza

  • Flu

  • Influenza With Non-Respiratory Manifestation

  • Influenza With Other Manifestations

  • Influenza, Human

  • Influenza, Susceptibility To

  • Seasonal Influenza, Virus Identified
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15325 UBA7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta UBA7 VGNC VGNC:78690
Bos taurus UBA7 VGNC VGNC:36566
Rattus norvegicus UBA7 RGD RGD:1308323
Felis catus UBA7 VGNC VGNC:66751
Mus musculus UBA7 MGD MGI:1349462
Canis familiaris UBA7 VGNC VGNC:48041
Others UBA7 NCBI