GNE-5472
GNE-5472 is a potent bifunctional ERα PRRTAC degrader, with its E3 ligand being a pan-IAP antagonist. GNE-5472 antagonizes cIAP1/2, activating the non-classical NF-κB pathway, resulting in a significant upregulation of TNFα expression. GNE-5472 inhibits the proliferation of breast cancer cells and induces cell apoptosis. GNE-5472 can be used for the study of breast cancer.
(Pink: Estrogen Receptor/ERR ligand (HY-18719); Blue: IAP ligand (HY-175446); Black: linker).
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- CAS No.: 2417369-99-2
- Formule: C59H73N7O9S
- Masse moléculaire:1056.32
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Voir tous les produits spécifiques à Isoform PROTACs
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Activité biologique
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ERα |
cIAP1 |
cIAP-2 |
NF-κB |
Chemical Information
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CAS No. 2417369-99-2
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Masse moléculaire 1056.32
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Formule C59H73N7O9S
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SMILES
CC/C(C1=CC=CC=C1)=C(C2=CC=C(O)C=C2)/C3=CC=C(C=C3)OCCN(C(CCOCCOCCC(NC4=NC(C5=CC=CC=C5)=C(NC([C@@H]6CCCN6C([C@@H](NC([C@H](C)NC)=O)C7CCCCC7)=O)=O)S4)=O)=O)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GNE-5472 Related Classifications
HY-175445 Related Classifications
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