JAK2-IN-22
JAK2-IN-22 is a bicyclic urea compound with potent binding inhibitory activity against wild-type and V617F mutant JH2 kinases (IC50 ≤ 10 nM). JAK2-IN-22 can be used in research related to various diseases including cancer.
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- CAS No.: 3057053-13-8
- Formule: C33H34FN7O5
- Masse moléculaire:627.67
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
JAK2wt |
JAK2V617F |
In Vitro
JAK2-IN-22 (Example 2) exhibits potent binding inhibitory activity against wild-type/V617F mutant JH2 (IC50 ≤ 10 nM), but shows almost no binding inhibitory effect on JH1 and no enzymatic inhibitory activity against V617F JAK2 (IC50 > 1000 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3057053-13-8
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Masse moléculaire 627.67
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Formule C33H34FN7O5
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SMILES
O=C1N([C@H]2C[C@@H](CC2)NC(OC)=O)C3=CC(NC4=CC(C5=CC(C#N)=CC=C5)=CC(NC(C6(CCOCC6)F)=O)=C4)=NC=C3N1C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JAK2-IN-22 Related Classifications
HY-188001 Related Classifications
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