Lysyllysine
Lysyllysine (L-Lysyl-L-lysine ) is an orally active PepT1 substrate. Lysyllysine enhances whole-body protein synthesis, improves intestinal structure, alleviates intestinal mucosal inflammation, and exhibits higher lysine bioavailability in neonatal piglets with PN-induced intestinal atrophy. Lysyllysine inhibits the growth of axenic cyanobacterial strains and induces their cell lysis. Lysyllysine can be used in studies related to intestinal atrophy and metabolism.
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- CAS No.: 13184-13-9
- Formule: C12H26N4O3
- Masse moléculaire:274.36
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDCK | IC50 |
10.9 mM
Compound: 48
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Binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells
Binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells
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[PMID: 16759105] |
In Vitro
Lysyllysine blocks growth and induces cell lysis in axenic cultures of Microcystis novacekii TAC 20-1 and Microcystis viridis NIES 102, with lower inhibitory activity than L-lysine monomer[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Yucatan miniature piglets (male, 7-8 days old, initial body weight 1.69 kg)[1]
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Dosage:0.50 g/kg/d
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Administration:enteral; continuous; 18 hours
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Result:Attained superior intestinal morphological indicators including jejunal mucosa weight 71 mg/cm, villus height 279 μm and small intestinal length 251 cm/kg body weight compared with the other two groups.
Achieved elevated whole-body protein synthesis (28 g/kg/day) and jejunal mucosal free lysine level (0.26 μmol/g tissue), outperforming free lysine and dipeptide combination groups.
Reduced jejunal mucosal myeloperoxidase activity significantly relative to the two control groups.
Upregulated occludin (relative expression = 2.8) and PepT1 (relative expression = 0.75) protein levels, with occludin higher than both reference groups and PepT1 higher than free lysine group only.
Boosted protein synthesis rates in liver, jejunal mucosa, gastrocnemius and longissimus dorsi muscle versus dipeptide combination group, showing no statistical difference from free lysine group.
Chemical Information
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CAS No. 13184-13-9
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Masse moléculaire 274.36
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Formule C12H26N4O3
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SMILES
NCCCC[C@H](NC([C@@H](N)CCCCN)=O)C(O)=O
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Synonyms
L-Lysyl-L-lysine
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lysyllysine Related Classifications
HY-120791 Related Classifications
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Keywords
- Lysyllysine
- 13184-13-9
- L-Lysyl-L-lysine
- Amino Acid Derivatives
- whole-body protein synthesis
- intestinal structure
- neonatal piglets
- axenic cyanobacterial strains
- PepT1
- lysine bioavailability
- PN-induced intestinal atrophy
- Microcystis viridis NIES 102
- intestinal mucosal inflammation
- Microcystis novacekii TAC 20-1
- Inhibitor
- inhibitor
- inhibit