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Pinzodirsen

Pinzodirsen (Compound ENTR-Oligo-0034) is a dystrophia myotonica protein kinase (DMPK) steric blocker. Pinzodirsen reduces the nuclear sequestration of toxic DMPK mRNA with splicing factors such as MBNL1 via steric blocking/relocation, or interferes with the secondary structure of CUG repeat RNA, instead of being cleaved by RNase H, thereby ameliorating systemic aberrant splicing in DM1. Pinzodirsen is applicable to the research of myotonic dystrophy.

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  • CAS No.: 2659211-29-5
  • Formule: C243H374N132O76P20
  • Masse moléculaire:6979.87
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Pinzodirsen Chemical Structure
    Pinzodirsen Chemical Structure
CAS No.: 2659211-29-5
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  • Pinzodirsen Chemical Structure
    Pinzodirsen Chemical Structure RNA, [P-deoxy-P-(dimethylamino)](2′,3′-dideoxy-2′,3′-imino-2′,3′-seco)(2′a→5′)(C-A-G-C-A-G-C-A-G-C-A-G-C-A-G-C-A-G-C-A-G)
    1/16
  • RNA, [P-deoxy-P-(dimethylamino)](2′,3′-dideoxy-2′,3′-imino-2′,3′-seco)(2′a→5′)(C-A-G-C-A-G-C-A-G-C-A-G-C-A-G-C-A-G-C-A-G)