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Cat. No.: HY-P11003

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PTD-N5-1

PTD-N5-1 is an IRF5 inhibitory peptide. PTD-N5-1 blocks the activation of IRF5. PTD-N5-1 inhibits β-glucan-induced IL-12 production in bone marrow-derived dendritic cells pre-stimulated with IFN-γ. PTD-N5-1 reduces the levels of IL-12 and IFN-γ in the kidneys of mice with Candida albicans infection. PTD-N5-1 is applicable to the research of Candida albicans infection.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2088834-68-6
Formule: C₁₄₈H₂₄₈N₅₂O₃₀S
Masse moléculaire:3267.95

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PTD-N5-1 Chemical Structure

CAS No.: 2088834-68-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

IRF5

IFN-γ

IL-12

Voir tous les produits spécifiques à Isoform Interleukin Related :

In Vitro

PTD-N5-1 (N5-1) (50 μM) completely blocks β-glucan-induced IL-12p70 production in IFN-γ-primed wild-type and Clec2d-deficient mouse bone marrow-derived dendritic cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA Assay^[1]

Cell Line:

IFN-γ-primed wild-type mouse bone marrow-derived dendritic cells (BMDCs), IFN-γ-primed Clec2d-deficient mouse bone marrow-derived dendritic cells (BMDCs)
Concentration:

50 μM
Incubation Time:

6 h (stimulation with curdlan plus IFN-γ; pretreatment prior to stimulation)
Result:

Completely blocked β-glucan-induced IL-12p70 production in IFN-γ-primed wild-type BMDCs.
Completely blocked β-glucan-induced IL-12p70 production in IFN-γ-primed Clec2d-deficient BMDCs.

In Vivo

PTD-N5-1 (N5-1) (100 μg/mouse) increases susceptibility to systemic C. albicans infection and reduces IL-12p70 and IFN-γ production in myeloid cell-specific Clec2d-deficient mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2088834-68-6
Masse moléculaire 3267.95
Formule C₁₄₈H₂₄₈N₅₂O₃₀S
Sequence

Asp-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Pro-Arg-Arg-Val-Arg-Leu-Lys
Sequence Shortening

DRQIKIWFQNRRMKWKKPRRVRLK
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Li F, et al. C-type lectin receptor 2d forms homodimers and heterodimers with TLR2 to negatively regulate IRF5-mediated antifungal immunity. Nature communications. 2023 Oct 23;14(1):6718. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références

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PTD-N5-1

Voir tous les produits spécifiques à Isoform Interleukin Related

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

PTD-N5-1 Related Classifications

HY-P11003 Related Classifications