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Cat. No.: HY-184799

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sEH-IN-25

sEH-IN-25 is an orally active soluble epoxide hydrolase (epoxide hydrolase) inhibitor, with an IC₅₀ of 0.5 nM against human sEH and an IC₅₀ of 2 nM against rat sEH. sEH-IN-25 can be used in the research of cardiovascular diseases.

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CAS No.: 1141896-04-9
Formule: C₁₉H₂₂BrF₃N₆O₂
Masse moléculaire:503.32

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

sEH-IN-25 Chemical Structure

CAS No.: 1141896-04-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- Parmacokinetics
Chemical Information
Protocole (1)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vitro

sEH-IN-25 potently inhibits soluble epoxide hydrolase activity in human embryonic kidney cells overexpressing human sEH with an IC₅₀ of 3 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Parmacokinetics

Species	Dose	Route	C_max	CL_plasma	T_1/2	V_dss	Bioavailability
Rat^[1]	2.0 mg/kg	i.v.	/	12 mL/min/kg	4.6 h	2.1 L/kg	100 %
Rat^[1]	0.2 mg/kg	p.o.	8 ng/mL	/	/	/	/
Rat^[1]	2.0 mg/kg	p.o.	112 ng/mL	/	/	/	/
Rat^[1]	20 mg/kg	p.o.	750 ng/mL	/	/	/	/

Chemical Information

CAS No. 1141896-04-9
Masse moléculaire 503.32
Formule C₁₉H₂₂BrF₃N₆O₂
SMILES

O=C(C1CCN(CC1)C2=NC(NC)=NC(C)=N2)NCC3=CC=C(C=C3OC(F)(F)F)Br
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Thalji RK, et al. Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase. Bioorganic & medicinal chemistry letters. 2013 Jun 15;23(12):3584-8. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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