100234-59-1
Chemical Structure
Picrasidine I
- CAS No.: 100234-59-1
- Formula:C14H12N2O2
- Molecular Weight:240.26
IUPAC Name: 4-methoxy-1-vinyl-9H-pyrido[3,4-b]indol-8-ol
InChIKey: JOHWQLSNGRWJRK-UHFFFAOYSA-N
SMILES: OC1=CC=CC2=C1NC3=C2C(OC)=CN=C3C=C
Biological Activity: Picrasidine I is an anti-inflammatory and anti-osteoclastogenic dimeric alkaloid that can be isolated from Picrasma quassioides. Picrasidine I inducs cell cycle arrest, and triggers cell apoptosis by downregulats ERK and Akt pathways. Picrasidine I inhibits the activation of MAPKs, NF-κB and ROS generation, and suppresses the expression of c-Fos and NFATc1[1][2].
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Picrasidine I | Picrasidine I is an anti-inflammatory and anti-osteoclastogenic dimeric alkaloid that can be isolated from Picrasma quassioides. Picrasidine I inducs cell cycle arrest, and triggers cell apoptosis by downregulats ERK and Akt pathways. Picrasidine I inhibits the activation of MAPKs, NF-κB and ROS generation, and suppresses the expression of c-Fos and NFATc1. | |||||||||||||||||||||
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- [1]. Ho HY, et al. Picrasidine I Triggers Heme Oxygenase-1-Induced Apoptosis in Nasopharyngeal Carcinoma Cells via ERK and Akt Signaling Pathways. Int J Mol Sci. 2022 May 29;23(11):6103. [Content Brief]
- [2]. Kong L, et al. Picrasidine I from Picrasma Quassioides Suppresses Osteoclastogenesis via Inhibition of RANKL Induced Signaling Pathways and Attenuation of ROS Production. Cell Physiol Biochem. 2017;43(4):1425-1435. [Content Brief]
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