1132746-02-1
1132746-02-1
Chemical Structure
Ropinirole-d3
Synonym(s): SKF 101468-d3
- CAS No.: 1132746-02-1
- Formula:C16H21D3N2O
- Molecular Weight:263.39
InChIKey: UHSKFQJFRQCDBE-CRSPMMAGSA-N
SMILES: CCCN(CCC)CCC1=C2C(NC(C2)=O)=C([2H])C([2H])=C1[2H]
Biological Activity: Ropinirole-d3 (SKF 101468-d3) is deuterium labeled Ropinirole. Ropinirole (SKF 101468) is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor. Ropinirole has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole has no affinity for the D1 receptors. Ropinirole has the potential for Parkinson's disease[1][2].
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Ropinirole-d3 | Ropinirole-d3 (SKF 101468-d3) is deuterium labeled Ropinirole. Ropinirole (SKF 101468) is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor. Ropinirole has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole has no affinity for the D1 receptors. Ropinirole has the potential for Parkinson's disease. | |||||||||||||||||||||
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Ropinirole-d14 | Ropinirole-d14 is the deuterium labeled Ropinirole. | |||||||||||||||||||||
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Ropinirole | 99.42% | Ropinirole (SKF 101468) is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor. Ropinirole has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole has no affinity for the D1 receptors. Ropinirole has the potential for Parkinson's disease. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Eden, R.J., et al., Preclinical pharmacology of ropinirole (SK&F 101468-A) a novel dopamine D2 agonist. Pharmacol Biochem Behav, 1991. 38(1): p. 147-54. [Content Brief]
