1202764-61-1
1202764-61-1
Chemical Structure
AM-0216
- CAS No.: 1202764-61-1
- Formula:C19H17N5OS
- Molecular Weight:363.44
IUPAC Name: (R)-4-(1-(2-aminopyrimidin-4-yl)indolin-6-yl)-2-(thiazol-2-yl)but-3-yn-2-ol
InChIKey: FSQNPXFFFUDCCO-LJQANCHMSA-N
SMILES: C(#C[C@@](C)(O)C1=NC=CS1)C=2C=C3N(CCC3=CC2)C4=NC(N)=NC=C4
Biological Activity: AM-0216 is a highly selective NF-κB-inducing kinase (NIK) inhibitor with a Ki value of 2 nM. AM-0216 is promising for research of NF-κB-dependent hematologic malignancies (e.g., multiple myeloma) and autoimmune diseases[1].
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AM-0216 | AM-0216 is a highly selective NF-κB-inducing kinase (NIK) inhibitor with a Ki value of 2 nM. AM-0216 is promising for research of NF-κB-dependent hematologic malignancies (e.g., multiple myeloma) and autoimmune diseases. | |||||||||||||||||||||
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References
Keywords
