120279-95-0
Chemical Structure
(4R,6R)-Dorzolamide
Synonym(s): (4R,6R)-L671152; (4R,6R)-MK507
- CAS No.: 120279-95-0
- Formula:C10H16N2O4S3
- Molecular Weight:324.44
InChIKey: IAVUPMFITXYVAF-HTRCEHHLSA-N
SMILES: O=S1(C2=C(C=C(S2)S(N)(=O)=O)[C@@H](C[C@H]1C)NCC)=O
Biological Activity: (4R,6R)-Dorzolamide ((4R,6R)-L671152; (4R,6R)-MK507) is a carbonic anhydrase II (CAII) inhibitor and the undesired chiral enantiomer of Dorzolamide. (4R,6R)-Dorzolamide inhibits CAII isoenzymes, thereby modulating the rate of aqueous humor formation. (4R,6R)-Dorzolamide serves as a stereoisomeric reference standard in chiral HPLC separation studies. (4R,6R)-Dorzolamide can be used for research on ocular hypertension and glaucoma[1][2][3][4].
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(4R,6R)-Dorzolamide | (4R,6R)-Dorzolamide ((4R,6R)-L671152; (4R,6R)-MK507) is a carbonic anhydrase II (CAII) inhibitor and the undesired chiral enantiomer of Dorzolamide. (4R,6R)-Dorzolamide inhibits CAII isoenzymes, thereby modulating the rate of aqueous humor formation. (4R,6R)-Dorzolamide serves as a stereoisomeric reference standard in chiral HPLC separation studies. (4R,6R)-Dorzolamide can be used for research on ocular hypertension and glaucoma. | |||||||||||||||||||||
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References
- [1]. Shamsipur M, et al. Chiral separation and quantitation of dorzolamide hydrochloride enantiomers by high-performance liquid chromatography. J Sep Sci. 2010 Aug;33(15):2328-33.
- [2]. Novak T J, et al. Determination of the enantiomeric composition of a novel topically active carbonic anhydrase inhibitor by HPLC. Journal of liquid chromatography & related technologies, 1998, 21(12): 1883-1896.
- [3]. Shamsipur M, et al. Development and validation of a new high performance liquid chromatographic method for enantioseparation of dorzolamide hydrochloride on a coated cellulose phenylcarbamate chiral stationary phase. Journal of liquid chromatography & related technologies, 2011, 34(14): 1367-1380.
- [4]. Dovletoglou A, et al. Development of practical HPLC methods for analysis and quality assessment of the novel carbonic anhydrase inhibitor MK-0507 and the acetamidosulfonamide intermediate. Journal of Liquid Chromatography & Related Technologies, 1995, 18(12): 2337-2352.
