country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-B0109H

Copy Link Print Information

(4R,6R)-Dorzolamide

Name: (4R,6R)-Dorzolamide
Brand: MedChemExpress
SKU: HY-B0109H
Availability: PreOrder

(Synonyms: (4R,6R)-L671152; (4R,6R)-MK507)

(4R,6R)-Dorzolamide ((4R,6R)-L671152; (4R,6R)-MK507) is a carbonic anhydrase II (CAII) inhibitor and the undesired chiral enantiomer of Dorzolamide. (4R,6R)-Dorzolamide inhibits CAII isoenzymes, thereby modulating the rate of aqueous humor formation. (4R,6R)-Dorzolamide serves as a stereoisomeric reference standard in chiral HPLC separation studies. (4R,6R)-Dorzolamide can be used for research on ocular hypertension and glaucoma.

For research use only. We do not sell to patients.

CAS No.: 120279-95-0
Formula: C₁₀H₁₆N₂O₄S₃
Molecular Weight:324.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(4R,6R)-Dorzolamide Chemical Structure

CAS No.: 120279-95-0

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

CA Ⅱ

All Carbonic Anhydrase Isoforms :

In Vivo

(4R,6R)-Dorzolamide ((4R,6R)-L671152; (4R,6R)-MK507) shows a less favorable binding orientation within the enzyme than the (4S,6S) isomer in animal models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 120279-95-0
Molecular Weight 324.44
Formula C₁₀H₁₆N₂O₄S₃
SMILES

O=S1(C2=C(C=C(S2)S(N)(=O)=O)[C@@H](C[C@H]1C)NCC)=O
Synonyms

(4R,6R)-L671152; (4R,6R)-MK507
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Shamsipur M, et al. Chiral separation and quantitation of dorzolamide hydrochloride enantiomers by high-performance liquid chromatography. J Sep Sci. 2010 Aug;33(15):2328-33.

[2]. Novak T J, et al. Determination of the enantiomeric composition of a novel topically active carbonic anhydrase inhibitor by HPLC. Journal of liquid chromatography & related technologies, 1998, 21(12): 1883-1896.

[3]. Shamsipur M, et al. Development and validation of a new high performance liquid chromatographic method for enantioseparation of dorzolamide hydrochloride on a coated cellulose phenylcarbamate chiral stationary phase. Journal of liquid chromatography & related technologies, 2011, 34(14): 1367-1380.

[4]. Dovletoglou A, et al. Development of practical HPLC methods for analysis and quality assessment of the novel carbonic anhydrase inhibitor MK-0507 and the acetamidosulfonamide intermediate. Journal of Liquid Chromatography & Related Technologies, 1995, 18(12): 2337-2352.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote