122-03-2
122-03-2
Chemical Structure
Cuminaldehyde
Synonym(s): p-Isopropylbenzaldehyde
- CAS No.: 122-03-2
- Formula:C10H12O
- Molecular Weight:148.21
IUPAC Name: 4-isopropylbenzaldehyde
InChIKey: WTWBUQJHJGUZCY-UHFFFAOYSA-N
SMILES: O=CC1=CC=C(C(C)C)C=C1
Biological Activity: Cuminaldehyde is the main component of Cuminum cyminum and has multiple biological activities, including anti-inflammatory, anti-cancer, anti-diabetic, anti-injury, anti-neuropathy and antibacterial effects. Cuminaldehyde is an inhibitor of aldose reductase (IC50= 0.00085 mg/mL), α-glucosidase (IC50=0.5 mg/mL) and lipoxygenase (IC50=1370 μM). Cuminaldehyde also inhibits the fibrillation of α-synuclein and prevents its aggregation. Cuminaldehyde has potential application value in the research of neurodegenerative diseases, cancer, diabetes and neuropathic pain diseases[1][2][3][4][5][6][7].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
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Cuminaldehyde | 99.32% | Cuminaldehyde is the main component of Cuminum cyminum and has multiple biological activities, including anti-inflammatory, anti-cancer, anti-diabetic, anti-injury, anti-neuropathy and antibacterial effects. Cuminaldehyde is an inhibitor of aldose reductase (IC50= 0.00085 mg/mL), α-glucosidase (IC50=0.5 mg/mL) and lipoxygenase (IC50=1370 μM). Cuminaldehyde also inhibits the fibrillation of α-synuclein and prevents its aggregation. Cuminaldehyde has potential application value in the research of neurodegenerative diseases, cancer, diabetes and neuropathic pain diseases. | ||||||||||||||||||||
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Cuminaldehyde (Standard) | 99.92% | Cuminaldehyde Standard is the analytical standard of Cuminaldehyde. This product is intended for research and analytical applications. Cuminaldehyde is the main component of Cuminum cyminum and has multiple biological activities, including anti-inflammatory, anti-cancer, anti-diabetic, anti-injury, anti-neuropathy and antibacterial effects. Cuminaldehyde is an inhibitor of aldose reductase (IC50= 0.00085 mg/mL) and α-glucosidase (IC50=0.5 mg/mL). Cuminaldehyde also inhibits the fibrillation of α-synuclein and prevents its aggregation Cuminaldehyde can induce apoptosis in colon adenocarcinoma cells by targeting topoisomerase I and II. In addition, Cuminaldehyde also exerts anti-inflammatory activity by inhibiting lipoxygenase. Cuminaldehyde has a strong inhibitory effect on the growth of Aspergillus flavus and the biosynthesis of aflatoxin B1 (AFB1). Cuminaldehyde can exert anti-injury and anti-neuropathy effects by participating in opioid receptors, L-arginine/NO/cGMP pathways and anti-inflammatory effects. Cuminaldehyde has potential application value in the research of neurodegenerative diseases, cancer, diabetes and neuropathic pain diseases. | ||||||||||||||||||||
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Nezukone | 98.81% | Nezukone is a derivative of hinokitiol. Hinokitiol can restore iron transports, however, Nezukone cannot bind or transport iron. | ||||||||||||||||||||
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Ibuprofen Impurity K (Standard) | ≥98% | Ibuprofen Impurity K (Standard) is the analytical standard of Ibuprofen Impurity K (HY-131260). This product is intended for research and analytical applications. Ibuprofen Impurity K is an impurity of Ibuprofen (HY-78131), a COX-1/COX-2 inhibitor with anti-inflammatory activity. Ibuprofen Impurity K also serves as an intermediate in the synthesis of loxoprofen (HY-B0578). | ||||||||||||||||||||
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4-Isopropylbenzyl alcohol | 99.48% | 4-Isopropylbenzyl alcohol (Cuminic alcohol) is an opioid-dependent analgesic. 4-Isopropylbenzyl alcohol activates opioid receptor, regulates the L-Arginine (HY-N0455)/NO/cGMP pathway, and reduces spinal cord TNF-α and IL-1β levels; it binds to BSA (HY-D0842) via static quenching. 4-Isopropylbenzyl alcohol can be used in research related to nociceptive pain, neuropathic pain, bacterial infection and diabetes. | ||||||||||||||||||||
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4-Bromobenzaldehyde-13C6 | 4-Bromobenzaldehyde-13C6 is the 13C labeled 4-Bromobenzaldehyde. | |||||||||||||||||||||
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4-Ethylbenzaldehyde (Standard) | ≥98% | 4-Ethylbenzaldehyde (Standard) is the analytical standard of 4-Ethylbenzaldehyde (HY-W012657). This product is intended for research and analytical applications. 4-Ethylbenzaldehyde is an aldehyde type organic compound with an almond-like odor. 4-Ethylbenzaldehyde is naturally present in various foods such as grilled meat, black tea, peanuts, etc. 4-Ethylbenzaldehyde has significant effects in controlling plant parasitic nematodes. 4-Ethylbenzaldehyde has genotoxicity and potential for liver damage in zebrafish models. | ||||||||||||||||||||
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p-Tolualdehyde | 99.10% | p-Tolualdehyde is the active small molecule, that could used as drug intermediate. | ||||||||||||||||||||
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4-Isopropylbenzoic acid | 99.94% | 4-Isopropylbenzoic acid (Cuminic acid; p-Isopropyl benzoic acid) an aromatic monoterpenoid, is isolated from the stem bark of Bridelia retusa. 4-Isopropylbenzoic acid exhibits antifungal activities. 4-Isopropylbenzoic acid is also a reversible and uncompetitive inhibitor of mushroom tyrosinase. | ||||||||||||||||||||
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p-Dimethylaminobenzaldehyde | 99.88% | p-Dimethylaminobenzaldehyde (4-Dimethylaminobenzaldehyde) can be used as a chromogenic reagent or as an absorbent agent for heavy metal ions. | ||||||||||||||||||||
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4-Methoxybenzaldehyde (Standard) | ≥98% | 4-Methoxybenzaldehyde (Standard) is the analytical standard of 4-Methoxybenzaldehyde. This product is intended for research and analytical applications. 4-Methoxybenzaldehyde (p-anisaldehyde) is a fragrant phenolic compound. 4-Methoxybenzaldehyde has been found in many plant species including horseradish, anise, star anise. 4-Methoxybenzaldehyde is a possible neurotoxicant and it has shown effects that include mortality, attractancy, and interference with host seeking . | ||||||||||||||||||||
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References
- [1]. Morshedi D, et al. Cuminaldehyde as the Major Component of Cuminum cyminum, a Natural Aldehyde with Inhibitory Effect on Alpha-Synuclein Fibrillation and Cytotoxicity. J Food Sci. 2015 Oct;80(10):H2336-45. [Content Brief]
- [2]. Tsai, et al. "Cuminaldehyde from Cinnamomum verum induces cell death through targeting topoisomerase 1 and 2 in human colorectal adenocarcinoma COLO 205 cells." Nutrients 8.6 (2016): 318. [Content Brief]
- [3]. Tomy, et al. "Cuminaldehyde as a lipoxygenase inhibitor: in vitro and in silico validation." Applied biochemistry and biotechnology 174 (2014): 388-397. [Content Brief]
- [4]. Wongkattiya, et al. "Antibacterial activity of cuminaldehyde on food-borne pathogens, the bioactive component of essential oil from Cuminum cyminum L. collected in Thailand." Journal of Complementary and Integrative Medicine 16.4 (2019). [Content Brief]
- [5]. Dan Xu, et al. "Cuminaldehyde in cumin essential oils prevents the growth and aflatoxin B1 biosynthesis of Aspergillus flavus in peanuts." Food Control 125 (2021): 107985.
- [6]. Koohsari, et al. "Antinociceptive and antineuropathic effects of cuminaldehyde, the major constituent of Cuminum cyminum seeds: Possible mechanisms of action." Journal of ethnopharmacology 255 (2020): 112786. [Content Brief]
- [7]. Hoi-Seon Lee, et al. "Cuminaldehyde: aldose reductase and α-glucosidase inhibitor derived from Cuminum cyminum L. seeds." Journal of agricultural and food chemistry 53.7 (2005): 2446-2450. [Content Brief]
