1240322-54-6
Chemical Structure
Antiproliferative agent-54
- CAS No.: 1240322-54-6
- Formula:C29H25F3N6O3
- Molecular Weight:562.54
IUPAC Name: methyl 5-((2-methyl-5-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzamido)benzyl)amino)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate
InChIKey: PGQWALGGBUYLQF-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=CC(NCC3=CC(NC(C4=CC(C(F)(F)F)=CC(N5C=C(C)N=C5)=C4)=O)=CC=C3C)=CN=C2N1)OC
Biological Activity: Antiproliferative agent-54 (Compound 6z) is the inhibitor for multiple kinases, such as ABL WT, B-RAF, EGFR, HCK, LYN A and SRC with IC50 of 6-50 nM. Antiproliferative agent-54 inhibits proliferation of several cancer cell, inhibits HUVEC and HepG2, with EC50 of 34 and 38 nM. Antiproliferative agent-54 exhibits good pharmacokinetic characteristics in rats[1].
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Antiproliferative agent-54 | Antiproliferative agent-54 (Compound 6z) is the inhibitor for multiple kinases, such as ABL WT, B-RAF, EGFR, HCK, LYN A and SRC with IC50 of 6-50 nM. Antiproliferative agent-54 inhibits proliferation of several cancer cell, inhibits HUVEC and HepG2, with EC50 of 34 and 38 nM. Antiproliferative agent-54 exhibits good pharmacokinetic characteristics in rats. | |||||||||||||||||||||
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