1257396-73-8
Chemical Structure
BIIB042
- CAS No.: 1257396-73-8
- Formula:C29H29F4NO2
- Molecular Weight:499.54
IUPAC Name: (R)-2-(6-((R)-(4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)propanoic acid
InChIKey: ONYWALXTZFPKAS-XHCCPWGMSA-N
SMILES: OC([C@H](C)C(C=C1)=CC(C2=CC=C(C(F)(F)F)C=C2)=C1[C@H](N3CCC(C)CC3)C4=CC=C(F)C=C4)=O
Biological Activity: BIIB042 is a potent, orally active, brain-penetrant, and selective γ-secretase modulator (GSM). BIIB042 reduces Aβ42 and increases Aβ38 levels in cells. BIIB042 significantly reduces brain Aβ42 levels in CF-1 mice and Fischer rats, as well as plasma Aβ42 levels in cynomolgus monkeys. BIIB042 reduces Aβ42 levels and Aβ plaque burden in Tg2576 mice. BIIB042 can be used for alzheimer's disease (AD) research[1][2].
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BIIB042 | BIIB042 is a potent, orally active, brain-penetrant, and selective γ-secretase modulator (GSM). BIIB042 reduces Aβ42 and increases Aβ38 levels in cells. BIIB042 significantly reduces brain Aβ42 levels in CF-1 mice and Fischer rats, as well as plasma Aβ42 levels in cynomolgus monkeys. BIIB042 reduces Aβ42 levels and Aβ plaque burden in Tg2576 mice. BIIB042 can be used for alzheimer's disease (AD) research. | |||||||||||||||||||||
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- [1]. Peng H, et al. Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable γ-Secretase Modulator. ACS Med Chem Lett. 2011 Aug 5;2(10):786-91. [Content Brief]
- [2]. Scannevin RH, et al. BIIB042, a novel γ-secretase modulator, reduces amyloidogenic Aβ isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's disease. Neuropharmacology. 2016 Apr;103:57-68. [Content Brief]
Keywords
