1261398-77-9
Chemical Structure
rel-Asenapine hydrochloride
Synonym(s): rel-Org 5222 hydrochloride
- CAS No.: 1261398-77-9
- Formula:C17H17Cl2NO
- Molecular Weight:322.23
InChIKey: FNJQDKSEIVVULU-CTHHTMFSSA-N
SMILES: CN1C[C@@]2([H])[C@@](C1)([H])C3=CC=CC=C3OC4=CC=C(Cl)C=C42.Cl
Biological Activity: rel-Asenapine (rel-Org 5222) hydrochloride is a relative configuration of Asenapine hydrochloride (HY-16567). Asenapine (Org 5222) hydrochloride, an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine hydrochloride can be used in the research of schizophrenia and bipolar disorder[1][2].
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rel-Asenapine hydrochloride | rel-Asenapine (rel-Org 5222) hydrochloride is a relative configuration of Asenapine hydrochloride (HY-16567). Asenapine (Org 5222) hydrochloride, an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine hydrochloride can be used in the research of schizophrenia and bipolar disorder. | |||||||||||||||||||||
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- [1]. Shahid M, et al. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J Psychopharmacol. 2009 Jan;23(1):65-73. [Content Brief]
- [2]. Olivia Frånberg, et al. Asenapine, a novel psychopharmacologic agent: preclinical evidence for clinical effects in schizophrenia. Psychopharmacology (Berl). 2008 Feb;196(3):417-29. [Content Brief]
Keywords
