1380508-60-0
Chemical Structure
AZ1136
- CAS No.: 1380508-60-0
- Formula:C24H21N5O3
- Molecular Weight:427.46
IUPAC Name: 6,9-dimethyl-2-(4-(oxazol-5-yl)phenoxy)-7-phenyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-e][1,4]diazepin-5-one
InChIKey: AWZRPYZJCCJQIQ-UHFFFAOYSA-N
SMILES: O=C1C2=CN=C(OC3=CC=C(C4=CN=CO4)C=C3)N=C2N(C)CC(C5=CC=CC=C5)N1C
Biological Activity: AZ1136 is a γ-secretase modulator that regulates amyloid-β (Aβ) production without reducing total Aβ generation. AZ1136 also modulates γ-secretase-mediated Notch S4 cleavage, but does not inhibit NICD formation. AZ1136 can be used in studies related to γ-secretase, APP processing and Alzheimer's disease[1][2][3].
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AZ1136 | AZ1136 is a γ-secretase modulator that regulates amyloid-β (Aβ) production without reducing total Aβ generation. AZ1136 also modulates γ-secretase-mediated Notch S4 cleavage, but does not inhibit NICD formation. AZ1136 can be used in studies related to γ-secretase, APP processing and Alzheimer's disease. | |||||||||||||||||||||
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- [1]. Olsson F, et al. Characterization of intermediate steps in amyloid beta (Aβ) production under near-native conditions. The Journal of biological chemistry. 2014 Jan 17;289(3):1540-50.
- [2]. Wanngren J, et al. Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production. The Journal of biological chemistry. 2012 Sep 21;287(39):32640-50. [Content Brief]
- [3]. Borgegard T, et al. First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanisms. The Journal of biological chemistry. 2012 Apr 06;287(15):11810-9. [Content Brief]
Keywords
