138531-51-8
Chemical Structure
Nolomirole hydrochloride
Synonym(s): CHF 1035
- CAS No.: 138531-51-8
- Formula:C19H28ClNO4
- Molecular Weight:369.88
IUPAC Name: 6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2-diyl bis(2-methylpropanoate) hydrochloride
InChIKey: TWTMQRXNAZGSCE-UHFFFAOYSA-N
SMILES: CC(C)C(OC1=C2C(CC(NC)CC2)=CC=C1OC(C(C)C)=O)=O.Cl
Biological Activity: Nolomirole (CHF 1035) hydrochloride is an orally active and selective DA2 dopaminergic receptor/α2-adrenoceptor agonist. Nolomirole attenuates the heart failure signs in the Monocrotaline (HY-N0750)-induced congestive heart failure model. Nolomirole increases cardiac output[1][2].
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Nolomirole hydrochloride | Nolomirole (CHF 1035) hydrochloride is an orally active and selective DA2 dopaminergic receptor/α2-adrenoceptor agonist. Nolomirole attenuates the heart failure signs in the Monocrotaline (HY-N0750)-induced congestive heart failure model. Nolomirole increases cardiac output. | |||||||||||||||||||||
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- [1]. Pasini E, et al. Effect of nolomirole on monocrotaline-induced heart failure. Pharmacol Res. 2004 Jan;49(1):1-5. [Content Brief]
- [2]. Torp-Pedersen C, et al. A randomised trial of a pre-synaptic stimulator of DA2-dopaminergic and alpha2-adrenergic receptors on morbidity and mortality in patients with heart failure. Eur J Heart Fail. 2008 Jan;10(1):89-95. [Content Brief]
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