139314-01-5
139314-01-5
Chemical Structure
Quilostigmine
Synonym(s): HP-290; NXX-066
- CAS No.: 139314-01-5
- Formula:C23H27N3O2
- Molecular Weight:377.48
IUPAC Name: (3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl 3,4-dihydroisoquinoline-2(1H)-carboxylate
InChIKey: IIFRKALDATVOJE-GGAORHGYSA-N
SMILES: O=C(N1CC2=C(C=CC=C2)CC1)OC3=CC4=C(N(C)[C@]5([H])[C@@]4(C)CCN5C)C=C3
Biological Activity: Quilostigmine (HP-290) is an orally active Physostigmine (HY-N6608) analogue, acetylcholinesterase (IC50: 148 nM for rat brain acetylcholinesterase) inhibitor. Quilostigmine has a long-lasting effect on tremors. Quetiapine can be used in the research of Alzheimer's disease[1][2].
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Quilostigmine | Quilostigmine (HP-290) is an orally active Physostigmine (HY-N6608) analogue, acetylcholinesterase (IC50: 148 nM for rat brain acetylcholinesterase) inhibitor. Quilostigmine has a long-lasting effect on tremors. Quetiapine can be used in the research of Alzheimer's disease. | |||||||||||||||||||||
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References
- [1]. Dahlin M, Björk E. Nasal administration of a physostigmine analogue (NXX-066) for Alzheimer's disease to rats. Int J Pharm. 2001 Jan 16;212(2):267-74. [Content Brief]
- [2]. Snape MF, et al. A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066. Neuropharmacology. 1999 Jan;38(1):181-93. [Content Brief]
