1426174-41-5
Chemical Structure
Ezetimibe phenoxy glucuronide-d4
Synonym(s): Ezetimibe glucuronide-d4;Ezetimibe β-D-glucuronide-d4
- CAS No.: 1426174-41-5
- Formula:C30H25D4F2NO9
- Molecular Weight:589.57
IUPAC Name: (2S,3S,4S,5R,6S)-6-(4-((2S,3R)-1-(4-fluorophenyl-2,3,5,6-d4)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-oxoazetidin-2-yl)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid
InChIKey: UOFYCFMTERCNEW-MKSNJYNSSA-N
SMILES: O[C@H]([C@H]([C@@H]([C@@H](C(O)=O)O1)O)O)[C@@H]1OC2=CC=C([C@H]([C@H]3CC[C@@H](C4=CC=C(F)C=C4)O)N(C5=C([2H])C([2H])=C(F)C([2H])=C5[2H])C3=O)C=C2
Biological Activity: Ezetimibe phenoxy glucuronide-d4 is the deuterium labeled Ezetimibe phenoxy glucuronide. Ezetimibe phenoxy glucuronide is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity[1]. Ezetimibe is a potent cholesterol absorption inhibitor[2].
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Ezetimibe phenoxy glucuronide-d4 | 89.34% | Ezetimibe phenoxy glucuronide-d4 is the deuterium labeled Ezetimibe phenoxy glucuronide. Ezetimibe phenoxy glucuronide is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity. Ezetimibe is a potent cholesterol absorption inhibitor. | ||||||||||||||||||||
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Ezetimibe phenoxy glucuronide | 99.77% | Ezetimibe phenoxy glucuronide (Ezetimibe glucuronide) is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity. Ezetimibe is a potent cholesterol absorption inhibitor. | ||||||||||||||||||||
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- [1]. Stolk MF, et al. Severe hepatic side effects of ezetimibe. Clin Gastroenterol Hepatol. 2006 Jul;4(7):908-11. [Content Brief]
- [2]. Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532. [Content Brief]
