185915-32-6
185915-32-6
Chemical Structure
MNA 279
Synonym(s): X 910279; HMR-279; FK-779
- CAS No.: 185915-32-6
- Formula:C14H11N3O2
- Molecular Weight:253.26
IUPAC Name: 2-cyano-N-(4-cyanophenyl)-3-cyclopropyl-3-oxopropanamide
InChIKey: GSSLQBZZKKOMAF-UHFFFAOYSA-N
SMILES: N#CC1=CC=C(NC(C(C(C2CC2)=O)C#N)=O)C=C1
Biological Activity: MNA 279 (X 910279) is an orally active, immunosuppressive malononitrilamide and A 771726 derivative. MNA 279 suppresses IgM and IgG antibody production. MNA 279 prevents the development of systemic lupus erythematosus (SLE)-like disease in mice. MNA 279 prolongs skin xenograft survival in a mouse-to-rat model[1][2].
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MNA 279 | MNA 279 (X 910279) is an orally active, immunosuppressive malononitrilamide and A 771726 derivative. MNA 279 suppresses IgM and IgG antibody production. MNA 279 prevents the development of systemic lupus erythematosus (SLE)-like disease in mice. MNA 279 prolongs skin xenograft survival in a mouse-to-rat model. | |||||||||||||||||||||
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References
- [1]. Schorlemmer HU, et al. Prevention of the development of murine systemic lupus erythematosus (SLE)-like diseases by the malononitrilamides MNA 279 and MNA 715. Inflamm Res. 1997 Aug;46 Suppl 2:S167-8. [Content Brief]
- [2]. Schorlemmer HU, et al. The new immunosuppressive malononitrilamide MNA 279 prolongs skin xenograft survival in a mouse-to-rat model. Transplant Proc. 1997 Dec;29(8):3497-500. [Content Brief]
