20862-11-7
Chemical Structure
(±)-Desisopropylpropranolol
Synonym(s): N-Desisopropylpropranolol
- CAS No.: 20862-11-7
- Formula:C13H15NO2
- Molecular Weight:217.26
IUPAC Name: 1-amino-3-(naphthalen-1-yloxy)propan-2-ol
InChIKey: ZFMCITCRZXLMDJ-UHFFFAOYSA-N
SMILES: C1=CC=C2C(=C1)C=CC=C2OCC(CN)O
Biological Activity: (±)-Desisopropylpropranolol (N-Desisopropylpropranolol) is a metabolite of Propranolol (HY-B0573B). Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Kis of 1.8 nM and 0.8 nM, respectively. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[1][2][3][4].
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(±)-Desisopropylpropranolol | (±)-Desisopropylpropranolol (N-Desisopropylpropranolol) is a metabolite of Propranolol (HY-B0573B). Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Kis of 1.8 nM and 0.8 nM, respectively. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy. | |||||||||||||||||||||
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- [1]. Galandrin S, et al. Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Mol Pharmacol. 2006 Nov;70(5):1575-84. [Content Brief]
- [2]. Briley M,et al. Evidence against beta-adrenoceptor blocking activity of diltiazem, a drug with calcium antagonist properties. Br J Pharmacol. 1980 Aug;69(4):669-73. [Content Brief]
- [3]. Al-Majed AA, et al. Propranolol. Profiles Drug Subst Excip Relat Methodol. 2017;42:287-338. [Content Brief]
- [4]. ZHAO L, et al. LC/MS/MS determination of propranolol and its metabolites 4-hydroxypropranolol and N-desisopropylpropranolol in rat plasma[J]. Chinese Journal of Pharmaceutical Analysis, 2005, 25(10): 1203-1206.
Keywords
