2093305-05-4
2093305-05-4
Chemical Structure
Fosgonimeton
Synonym(s): ATH-1017
- CAS No.: 2093305-05-4
- Formula:C27H45N4O8P
- Molecular Weight:584.64
IUPAC Name: 4-((S)-3-(((2S,3S)-1-((6-amino-6-oxohexyl)amino)-3-methyl-1-oxopentan-2-yl)amino)-2-hexanamido-3-oxopropyl)phenyl dihydrogen phosphate
InChIKey: MBYDCPOKVKDSFD-JTJYXVOQSA-N
SMILES: O=P(O)(O)OC(C=C1)=CC=C1C[C@H](NC(CCCCC)=O)C(N[C@@H]([C@@H](C)CC)C(NCCCCCC(N)=O)=O)=O
Biological Activity: Fosgonimeton (ATH-1017) is a hepatocyte growth factor receptor (c-Met/HGFR) agonist. Fosgonimeton has neuroprotective effects in both LPS (HY-D1056) -induced neuroinflammation and Aβ-induced AD models[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Fosgonimeton | 98.24% | Fosgonimeton (ATH-1017) is a hepatocyte growth factor receptor (c-Met/HGFR) agonist. Fosgonimeton has neuroprotective effects in both LPS (HY-D1056) -induced neuroinflammation and Aβ-induced AD models. | ||||||||||||||||||||
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References
- [1]. Reda S, et al. Fosgonimeton, a novel, small molecule positive modulator of the HGF/MET system is neuroprotective in primary neuron culture. Alzheimer's Dement. 2022 18: e065874.
- [2]. Reda SM, et al. Fosgonimeton attenuates amyloid-beta toxicity in preclinical models of Alzheimer's disease. Neurotherapeutics. 2024 Jul;21(4):e00350. [Content Brief]
- [3]. Johnston JL, et al. Fosgonimeton, a Novel Positive Modulator of the HGF/MET System, Promotes Neurotrophic and Procognitive Effects in Models of Dementia. Neurotherapeutics. 2023 Mar;20(2):431-451. [Content Brief]
- [4]. Leen H. KAWAS, et al. WO2017210489. 2021.
