2094991-62-3
Chemical Structure
CPAG-1
- CAS No.: 2094991-62-3
- Formula:C20H26N2O2
- Molecular Weight:326.43
InChIKey: JDNPODJHHKYEDR-SFHVURJKSA-N
SMILES: CC(C[C@@H](C(NC1=CC=C2C=CC=CC2=C1)=O)NC(CCC)=O)C
Biological Activity: CPAG-1 is a small-molecule activator of progesterone receptor membrane component 2 (PGRMC2). CPAG-1 can enhance mitochondrial heme delivery to the nucleus mediated by PGRMC2 and activate genes related to heat production in brown adipose tissue (BAT), such as Ucp1 and Pgc-1α, and reduce lipid accumulation in BAT. CPAG-1 reduce fasting blood sugar and insulin levels, and improve glucose tolerance and insulin sensitivity. CPAG-1 can be used for research of type 2 diabetes[1].
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CPAG-1 | CPAG-1 is a small-molecule activator of progesterone receptor membrane component 2 (PGRMC2). CPAG-1 can enhance mitochondrial heme delivery to the nucleus mediated by PGRMC2 and activate genes related to heat production in brown adipose tissue (BAT), such as Ucp1 and Pgc-1α, and reduce lipid accumulation in BAT. CPAG-1 reduce fasting blood sugar and insulin levels, and improve glucose tolerance and insulin sensitivity. CPAG-1 can be used for research of type 2 diabetes. | |||||||||||||||||||||
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Keywords
