214287-88-4
Chemical Structure
DPC 961
Synonym(s): (S)-DPC 961; DMP 961
- CAS No.: 214287-88-4
- Formula:C14H10ClF3N2O
- Molecular Weight:314.69
IUPAC Name: (S)-6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one
InChIKey: JJWJSIAJLBEMEN-ZDUSSCGKSA-N
SMILES: FC(F)(F)[C@@]1(C2=CC(Cl)=CC=C2NC(N1)=O)C#CC3CC3
Biological Activity: DPC 961 (DMP 961) is a non-nucleoside reverse transcriptase inhibitor (NNRTI). DPC 961 is a potent and specific inhibitor of HIV-1 reverse transcriptase, which inhibits the activity of HIV-1 reverse transcriptase in a non-competitive manner, thereby preventing viral replication. DPC 961 can be used for research on AIDS[1].
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DPC 961 | DPC 961 (DMP 961) is a non-nucleoside reverse transcriptase inhibitor (NNRTI). DPC 961 is a potent and specific inhibitor of HIV-1 reverse transcriptase, which inhibits the activity of HIV-1 reverse transcriptase in a non-competitive manner, thereby preventing viral replication. DPC 961 can be used for research on AIDS. | |||||||||||||||||||||
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- [1]. Mutlib A, et al. Characterization of Novel Glutathione Adducts of a Non-Nucleoside Reverse Transcriptase Inhibitor,(S)-6-Chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-3, 4-dihydro-2 (1 H)-quinazolinone (DPC 961), in Rats. Possible Formation of an Oxirene Metabolic Intermediate from a Disubstituted Alkyne[J]. Chemical research in toxicology, 2000, 13(8): 775-784. [Content Brief]
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