2367619-87-0
2367619-87-0
Chemical Structure
FPFT-2216
- CAS No.: 2367619-87-0
- Formula:C12H12N4O3S
- Molecular Weight:292.31
IUPAC Name: 3-(4-(4-methoxythiophen-3-yl)-1H-1,2,3-triazol-1-yl)piperidine-2,6-dione
InChIKey: SKUSCUALKIOIST-UHFFFAOYSA-N
SMILES: O=C(C(N1N=NC(C2=CSC=C2OC)=C1)CC3)NC3=O
Biological Activity: FPFT-2216, a “molecular glue” compound, degrades phosphodiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3), and casein kinase 1α (CK1α). FPFT-2216 can be used for the research of cancer and inflammatory disease[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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FPFT-2216 | 99.55% | FPFT-2216, a “molecular glue” compound, degrades phosphodiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3), and casein kinase 1α (CK1α). FPFT-2216 can be used for the research of cancer and inflammatory disease. | ||||||||||||||||||||
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References
- [1]. Teng M, et al. Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. J Med Chem. 2022 Jan 13;65(1):747-756. [Content Brief]
- [2]. Gemechu Y, et al. Humanized cereblon mice revealed two distinct therapeutic pathways of immunomodulatory drugs. Proc Natl Acad Sci U S A. 2018;115(46):11802-11807. [Content Brief]
Keywords
