2376724-98-8
Chemical Structure
308-R
- CAS No.: 2376724-98-8
- Formula:C23H23FN6O4S
- Molecular Weight:498.53
IUPAC Name: 2-((2-((2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide
InChIKey: UAVUYSNDFXWICV-QGZVFWFLSA-N
SMILES: CC1=CC=C(C(S(=O)(NC2=CC=C(C=C2)C3=NC(OC[C@H]4CNCCO4)=C5C=NNC5=N3)=O)=C1)F
Biological Activity: 308-R is a SGK3/SGK1/S6K1 inhibitor. 308-R exhibits an IC50 of 5 nM against human SGK3, an IC50 of 10 nM against human SGK1, and an IC50 of 1 nM against human S6K1. 308-R can be used in breast cancer research. It is also applicable to studies related to PROTAC synthesis, such as serving as the target protein ligand for PROTAC SGK3 degrader-2 (HY-176823)[1].
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308-R | 308-R is a SGK3/SGK1/S6K1 inhibitor. 308-R exhibits an IC50 of 5 nM against human SGK3, an IC50 of 10 nM against human SGK1, and an IC50 of 1 nM against human S6K1. 308-R can be used in breast cancer research. It is also applicable to studies related to PROTAC synthesis, such as serving as the target protein ligand for PROTAC SGK3 degrader-2 (HY-176823). | |||||||||||||||||||||
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Keywords
